Document Detail

Differential effects of corticosteroids and pimecrolimus on the developing skin immune system in humans and mice.
MedLine Citation:
PMID:  19295616     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis arises primarily in early infancy. In these patients, corticosteroids are used especially with great caution because of their side effects. Calcineurin inhibitors such as pimecrolimus (PIM) could be useful, but safety concerns have been raised in particular because of the lack of knowledge about their effects on the developing skin immune system. This study was designed to investigate the impact of PIM and corticosteroids on epidermal cells (EC) in infants and newborn mice. We found that the percentage of unfractionated viable infant ECs was significantly decreased in the presence of beta-methasone-17-valerate (BMV) but not PIM. Exposure of unfractionated infant ECs to BMV but not to PIM and vehicle control caused a significant inhibition of the upregulation of CD86 molecules on Langerhans cells (LC). The release of cytokines by LCs and ECs, cultured in the presence of BMV and PIM, was not significantly reduced compared with controls. Topical corticosteroid but not PIM application onto newborn mice induced apoptosis in some LC precursors. Our data suggest that similar to the situation in adult skin, corticosteroids may impair LC maturation as well as viability of ECs in infants, effects not seen with PIM.
Simone Meindl; Christine Vaculik; Josef G Meingassner; Gero Kramer; Johnnie Akgün; Marion Prior; Anton Stuetz; Georg Stingl; Adelheid Elbe-Bürger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-19
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-10-22     Revised Date:  2011-09-29    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2184-92     Citation Subset:  IM    
Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Vienna Competence Center, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Adrenal Cortex Hormones / toxicity*
Apoptosis / drug effects
Betamethasone 17-Valerate / toxicity
Cell Survival / drug effects
Cells, Cultured
Cytokines / biosynthesis
Infant, Newborn
Keratinocytes / drug effects,  immunology
Langerhans Cells / drug effects,  immunology
Mice, Inbred BALB C
Skin / cytology,  drug effects*,  immunology
Stem Cells / drug effects
Tacrolimus / analogs & derivatives*,  toxicity
Grant Support
P 19474-B13//Austrian Science Fund FWF
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Cytokines; 0/pimecrolimus; 109581-93-3/Tacrolimus; 2152-44-5/Betamethasone 17-Valerate

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