| Differential effects of clonidine analogs on food intake in rabbits and monkeys. | |
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MedLine Citation:
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PMID: 2622999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the effect of structural analogs of clonidine on feeding in both rabbits and monkeys. In rabbits, lofexidine and tizanidine either did not influence or decreased food intake in contrast to clonidine, which stimulated food intake. Lofexidine elicited easily observed decreases in motor behavior with several of the doses used in the study. Changes in motor behavior induced by tizanidine were more subtle. Conversely, lofexidine and tizanidine significantly increased feeding behavior in Stumptail macaque monkeys, as did clonidine. The results suggest that, in contrast to rabbits, Stumptail monkeys are more useful in searching for an 'orectic' effect of clonidine analogs. |
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Authors:
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N L Katz; N Sobaski; J Sanchez; J E Young; R F Schlemmer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 34 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-03-27 Completed Date: 1990-03-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, College of Pharmacy, University of Illinois, Chicago 60612. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clonidine / administration & dosage, analogs & derivatives, pharmacology* Dose-Response Relationship, Drug Eating / drug effects* Feeding Behavior / drug effects Female Macaca Male Rabbits Sodium Chloride / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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31036-80-3/lofexidine; 4205-90-7/Clonidine; 51322-75-9/tizanidine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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