Document Detail


Differential effects of clonidine analogs on food intake in rabbits and monkeys.
MedLine Citation:
PMID:  2622999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined the effect of structural analogs of clonidine on feeding in both rabbits and monkeys. In rabbits, lofexidine and tizanidine either did not influence or decreased food intake in contrast to clonidine, which stimulated food intake. Lofexidine elicited easily observed decreases in motor behavior with several of the doses used in the study. Changes in motor behavior induced by tizanidine were more subtle. Conversely, lofexidine and tizanidine significantly increased feeding behavior in Stumptail macaque monkeys, as did clonidine. The results suggest that, in contrast to rabbits, Stumptail monkeys are more useful in searching for an 'orectic' effect of clonidine analogs.
Authors:
N L Katz; N Sobaski; J Sanchez; J E Young; R F Schlemmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  34     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-27     Completed Date:  1990-03-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacodynamics, College of Pharmacy, University of Illinois, Chicago 60612.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clonidine / administration & dosage,  analogs & derivatives,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Feeding Behavior / drug effects
Female
Macaca
Male
Rabbits
Sodium Chloride / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
31036-80-3/lofexidine; 4205-90-7/Clonidine; 51322-75-9/tizanidine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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