Document Detail


Differential effects of chronic social stress and fluoxetine on meal patterns in mice.
MedLine Citation:
PMID:  23318656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both chronic stress and antidepressant medications have been associated with changes in body weight. In the current study, we investigate mechanisms by which stress and antidepressants interact to affect meal patterns. A group of mice was subjected to the chronic social defeat stress model of major depression followed by fluoxetine treatment and was subsequently analyzed for food intake using metabolic cages. We report that chronic social defeat stress increases food intake by specifically increasing meal size, an effect that is reversed by fluoxetine treatment. In an attempt to gain mechanistic insight into changes in meal patterning induced by stress and fluoxetine, fasting serum samples were collected every 4h over a 24-h period, and acyl-ghrelin, leptin, and corticosterone levels were measured. Chronic stress induces a peak in acyl-ghrelin levels just prior to the onset of the dark phase, which is shifted in mice treated with fluoxetine. Taken together, these results indicate that stress increases food intake by decreasing satiation, and that fluoxetine can reverse stress-induced changes in meal patterns.
Authors:
Jaswinder Kumar; Jen-Chieh Chuang; Elisa S Na; Anna Kuperman; Andrea G Gillman; Shibani Mukherjee; Jeffrey M Zigman; Colleen A McClung; Michael Lutter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-11
Journal Detail:
Title:  Appetite     Volume:  64     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-22     Completed Date:  2013-09-09     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidepressive Agents, Second-Generation / pharmacology*
Chronic Disease
Corticosterone / blood
Eating* / drug effects
Energy Intake* / drug effects
Fluoxetine / pharmacology,  therapeutic use*
Ghrelin / blood
Leptin / blood
Meals* / drug effects
Mice
Obesity* / blood,  etiology,  prevention & control
Satiation / drug effects
Serotonin Uptake Inhibitors / pharmacology,  therapeutic use
Social Environment
Stress, Psychological / complications*
Grant Support
ID/Acronym/Agency:
K08 MH084058/MH/NIMH NIH HHS; K08 MH084058-1A1/MH/NIMH NIH HHS; R01 DA023988/DA/NIDA NIH HHS; R01 MH082876/MH/NIMH NIH HHS; R01 MH082876/MH/NIMH NIH HHS; R01 MH085298/MH/NIMH NIH HHS; R01 MH085298/MH/NIMH NIH HHS; RL1 DK081182/DK/NIDDK NIH HHS; RL1 DK081185/DK/NIDDK NIH HHS; T32-MH076690-05/MH/NIMH NIH HHS; UL1RR024923/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Ghrelin; 0/Leptin; 0/Serotonin Uptake Inhibitors; 01K63SUP8D/Fluoxetine; W980KJ009P/Corticosterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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