Document Detail


Differential effects of catecholamines on in vitro growth of pathogenic bacteria.
MedLine Citation:
PMID:  12044844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Supplementation of minimal medium inoculated with bacterial cultures with norepinephrine, epinephrine, dopamine, or isoproterenol resulted in marked increases in growth compared to controls. Norepinephrine and dopamine had the greatest enhancing effects on growth of cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae, while epinephrine and isoproterenol also enhanced growth to a lesser extent. The growth of Escherichia coli in the presence of norepinephrine was greater than growth in the presence of the three other neurochemicals used in the study. Growth of Staphylococcus aureus was also enhanced in the presence of norepinephrine, but not to the same degree as was the growth of gram negative bacteria. Addition of culture supernatants from E. coli cultures that had been grown in the presence of norepinephrine was able to enhance the growth of K. pneumoniae. Addition of the culture supernatant fluid culture from E. coli cultures that had been grown in the presence of norepinephrine did not enhance growth of P. aeruginosa or S. aureus. Culture supernatant fluids from bacteria other than E. coli grown in the presence of norepinephrine were not able to enhance the growth of any bacteria tested. The results suggest that catecholamines can enhance growth of pathogenic bacteria, which may contribute to development of pathogenesis; however, there is no uniform effect of catecholamines on bacterial growth.
Authors:
Tesfaye Belay; Gerald Sonnenfeld
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  71     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-56     Citation Subset:  IM; S    
Affiliation:
Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Drive, S.W., Atlanta, GA 30310, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anti-Bacterial Agents / pharmacology*
Catecholamines / pharmacology*
Cell Division / drug effects
Escherichia coli / drug effects*
Klebsiella pneumoniae / drug effects
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects*
Staphylococcus aureus / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Catecholamines
Investigator
Investigator/Affiliation:
G Sonnenfeld / Morehouse Sch Med, Atlanta, GA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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