| Differential effects of carvedilol and atenolol on plasma noradrenaline during exercise in humans. | |
| | |
MedLine Citation:
|
PMID: 12580984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Evidence of long-term beneficial effects of beta-blockers on mortality and morbidity in patients with heart failure has been demonstrated in recent randomized trials. However, not all beta-blockers are identical. Carvedilol, a nonselective beta- and alpha-adrenergic blocker, can potentially blunt the release of noradrenaline by blocking presynaptic beta2-adrenergic receptors. To test this hypothesis, we have compared the effects of carvedilol and atenolol on plasma noradrenaline during exercise in healthy young volunteers. METHODS: This study investigated the differential effects of 2 weeks pretreatment with carvedilol 25 mg day(-1) and atenolol 50 mg day(-1) on plasma noradrenaline at rest and during exercise on a treadmill in a double-blind randomized crossover study, involving 12 healthy male volunteers (mean age 21.6 +/- 0.3 years). RESULTS: Haemodynamic parameters at rest and during exercise were not significantly different in either carvedilol or atenolol pretreatment groups. However, carvedilol pretreatment significantly blunted the increase in plasma noradrenaline during exercise [393.8 +/- 51.7 pg ml(-1) (pretreatment) to 259.7 +/- 21.2 pg ml(-1) (post-treatment)], when compared with atenolol [340.4 +/- 54.6 pg ml(-1) (pretreatment) to 396.2 +/- 32.0 pg ml(-1) (post-treatment)]. The difference between carvedilol and atenolol (95% confidence interval) was -145.2, -351.0, P < 0.05. CONCLUSIONS: We have demonstrated that carvedilol but not atenolol significantly blunted the increase in plasma noradrenaline during exercise. These findings may suggest a sympathoinhibitory effect of carvedilol that may enhance its ability to attenuate the cardiotoxicity associated with adrenergic stimulation in patients with heart failure. |
| | |
Authors:
|
Rahmatina B Herman; Peter J Jesudason; Ali M Mustafa; Ruby Husain; Anna Maria J Choy; Chim C Lang |
Related Documents
:
|
21806634 - The effect of major depression on postexercise cardiovascular recovery. 9192124 - Exercise metabolism in healthy volunteers taking celiprolol, atenolol, and placebo. 7828294 - Role of cardiac beta 2-receptors in cardiac responses to exercise in cardiac transplant... 1680114 - Beta-blocker therapy: identification and management of side effects. 374684 - Sympathetic activity and transcendental meditation. 8240194 - Seven-day pyridostigmine administration and thermoregulation during rest and exercise i... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 55 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-02-12 Completed Date: 2003-04-28 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 134-8 Citation Subset: IM |
Affiliation:
|
Faculty of Medicine, University of Andalas, Indonesia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adrenergic beta-Antagonists / administration & dosage, pharmacology* Adult Atenolol / administration & dosage, pharmacology* Blood Pressure / drug effects Carbazoles / administration & dosage, pharmacology* Cross-Over Studies Double-Blind Method Exercise / physiology* Exercise Test Heart Rate / drug effects Humans Male Norepinephrine / blood* Propanolamines / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 29122-68-7/Atenolol; 51-41-2/Norepinephrine; 72956-09-3/carvedilol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen t...
Next Document: Blood pressure response to conventional and low-dose enalapril in chronic renal failure.