Document Detail

Differential effects of busulfan on gonadal development in five divergent anuran species.
MedLine Citation:
PMID:  22609225     Owner:  NLM     Status:  Publisher    
The aim of this paper was to investigate the effects of germ cell depletion on the sexual differentiation of gonads in five anuran species. We used busulfan to eliminate the germ cells. Our results indicate that germ cells are not required for gonadal ridge formation or the development of the undifferentiated gonads. We observed a gradual degeneration of gonads in studied species and the transdifferentiation of the whole gonads into large fat bodies in Xenopus laevis. In the latter the sexual differentiation of gonads or seminiferous tubules were not impaired in the absence of germ cells. Thus, the X. laevis may serve as a model to study the human Del Castillo syndrome. Our study shows that in anuran amphibians the germ cells are not necessary for the formation of the testis, but they are crucial for development of the ovaries and are required for the maintenance of the gonadal structure.
Rafał P Piprek; Anna Pecio; Jacek Z Kubiak; Jacek M Szymura
Related Documents :
9271845 - Cell wall analysis in aspergillus niger strains characterized by different tolerance to...
2046695 - Genotoxicity of the boldine aporphine alkaloid in prokaryotic and eukaryotic organisms.
1280275 - Identification of a transitional cell state in the developmental pathway to carrot soma...
10209765 - Yarrowia lipolytica cell wall architecture: interaction of ywp1, a mycelial protein, wi...
3395345 - Cell-cycle dependent transformation competence in dictyostelium discoideum.
21881585 - Dihydrotestosterone-inducible il-6 inhibits elongation of human hair shafts by suppress...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-15
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  -     ISSN:  1873-1708     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Department of Comparative Anatomy, Institute of Zoology, Jagiellonian University, Grononstajowa 9, 30-387 Kraków, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of the electrocardiogram in identifying and quantifying lateral involvement in nonanterio...
Next Document:  A multifaceted model for risk assessment of violent behaviour in acutely admitted psychiatric patien...