Document Detail

Differential effects of anticytoskeletal compounds on the localization and chemical patterns of actin in germinating conidia of Neurospora crassa.
MedLine Citation:
PMID:  8472908     Owner:  NLM     Status:  MEDLINE    
Anti-actin drugs, cytochalasins A and B, inhibited both normal single, and benomyl-induced multiple, germ tube outgrowth from conidia of Neurospora crassa. Actin was cytochemically found to be concentrated in each of the benomyl-induced germ tube tips. No significant quantitative changes either in total actin or its isoforms were measured in the inhibitor-treated germlings. While intact microtubules are required for normal, monopolar axiation of the germ tube, they appear not to be necessary for benomyl-induced multipolar outgrowth which, in contrast, still requires intact actin microfilaments. Microfilaments and microtubules thus play complementary roles in the normal germination of conidia.
F Barja; M L Chappuis; G Turian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  107     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-20     Completed Date:  1993-05-20     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Laboratory of General Microbiology, University of Geneva, Switzerland.
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MeSH Terms
Actins / metabolism*
Benomyl / pharmacology
Cytochalasin B / pharmacology
Cytochalasins / pharmacology
Cytoskeleton / drug effects*
Neurospora crassa / drug effects*,  growth & development,  metabolism*
Reg. No./Substance:
0/Actins; 0/Cytochalasins; 14110-64-6/cytochalasin A; 14930-96-2/Cytochalasin B; 17804-35-2/Benomyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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