Document Detail

Differential effects of angiotensin II and eledoisin on monoamine oxidase A and B activities in rat brain.
MedLine Citation:
PMID:  1899693     Owner:  NLM     Status:  MEDLINE    
Intracerebroventricular injections of angiotensin II caused 108, 62, and 54% increases in monoamine oxidase A activities in rat hippocampus, hypothalamus, and striatum, respectively. These activatory effects were abolished by simultaneous injections of eledoisin. No significant changes of monoamine oxidase B activities were found under the same experimental conditions. Neither angiotensin II nor elodoisin changed substrate/inhibitor affinities of both isoenzymes. These data indicate that angiotensin II and tachykinin transmitter systems may exert opposite, long-term regulatory effects on monoaminergic neurons in rat brain.
M Tomaszewicz; L G Micossi; H Bielarczyk; D Luszawska; I Santarelli; A Szutowicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  56     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  729-32     Citation Subset:  IM    
Department of Clinical Biochemistry, Medical Academy, Gdansk, Poland.
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MeSH Terms
Angiotensin II / pharmacology*
Benzylamines / antagonists & inhibitors
Brain / enzymology*,  metabolism
Clorgyline / pharmacology
Eledoisin / pharmacology*
Injections, Intraventricular
Isotonic Solutions / pharmacology
Monoamine Oxidase / metabolism*
Octopamine / antagonists & inhibitors
Rats, Inbred Strains
Selegiline / pharmacology
Tissue Distribution
Reg. No./Substance:
0/Benzylamines; 0/Isotonic Solutions; 0/Tyrode's solution; 100-46-9/benzylamine; 104-14-3/Octopamine; 11128-99-7/Angiotensin II; 14611-51-9/Selegiline; 17780-72-2/Clorgyline; 69-25-0/Eledoisin; EC Oxidase

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