| Differential effects of anesthetics on electrical properties of the rainbow trout (Oncorhynchus mykiss) heart. | |
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MedLine Citation:
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PMID: 16905348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared electrocardiographic signals in hatchery-reared, non-spinally-transected, immature rainbow trout (Oncorhynchus mykiss Walbaum) under clove oil (25 ppm), tricaine methanesulfonate (tricaine, 60 ppm), and benzocaine (108 ppm) general anesthesia (35 min, 14 degrees C). For all 3 anesthetics, the mean heart rate (HR) and QRS amplitude did not differ, and QRS duration and QT interval were independent of HR. Heart rate variability (HRV) was significantly (4-fold, P=0.032) higher under benzocaine than under clove oil and tricaine, but did not differ between clove oil and tricaine. QRS duration differed between groups (P<0.001, F=121); benzocaine anesthesia resulted in longer QRS complexes compared to clove oil (P<0.001) and tricaine (P<0.001) anesthesia, and QRS complexes under clove oil were longer than those under tricaine (P<0.001). High HRV and QRS amplitude variation with benzocaine were associated with HR oscillations as anesthetic exposure time increased, and suggest benzocaine toxicity which may influence cardiac function studies. Similar clove oil and tricaine ECG patterns suggest comparable autonomic effects, and maintenance of myocardial excitability. Given its low cost, ease of use, and similar ECG profiles to tricaine, clove oil is a viable alternative for studies of cardiac function in anesthetized rainbow trout. |
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Authors:
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P A Cotter; K J Rodnick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-07 |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 145 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-25 Completed Date: 2006-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 158-65 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Idaho State University, Pocatello, ID 83209-8007, USA. afpac1@uaa.alaska.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminobenzoic Acids
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pharmacology* Anesthetics / pharmacology* Animals Benzocaine / pharmacology* Clove Oil / pharmacology* Electrocardiography / drug effects Female Heart / drug effects, physiology Heart Rate / drug effects Male Oncorhynchus mykiss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Aminobenzoic Acids; 0/Anesthetics; 0/Clove Oil; 582-33-2/tricaine; 94-09-7/Benzocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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