Document Detail


Differential effects of alcohol on contrast processing mediated by the magnocellular and parvocellular pathways.
MedLine Citation:
PMID:  23090614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated how acute alcohol intake affects contrast processing mediated by inferred magnocellular (MC) and parvocellular (PC) pathways. Achromatic contrast discrimination thresholds were measured in 16 young healthy participants using a steady-pedestal, pulsed-pedestal or pedestal-Δ-pedestal paradigm designed to favor the inferred MC or the PC pathway. Each participant completed two randomized sessions that included consumption of either 0.8 g/kg alcohol or a placebo beverage, with each session consisting of contrast discrimination measurements at baseline and at 60 min following beverage consumption. The results showed that, compared to placebo, alcohol significantly reduced MC contrast sensitivity and PC contrast gain but had no effect on PC contrast sensitivity for the majority of the participants; and did not alter MC contrast gain consistently across participants. The decrease in contrast gain in the PC pathway can be interpreted as a degradation of the postretinal signal-to-noise ratio, whereas the decrease of sensitivity in the MC pathway likely results from a change of cortical processing.
Authors:
Xiaohua Zhuang; Andrea King; Patrick McNamara; Joel Pokorny; Dingcai Cao
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-22
Journal Detail:
Title:  Journal of vision     Volume:  12     ISSN:  1534-7362     ISO Abbreviation:  J Vis     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-23     Completed Date:  2013-03-12     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101147197     Medline TA:  J Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. xzhuang@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Central Nervous System Depressants / pharmacology
Color Vision Defects / chemically induced*,  physiopathology
Contrast Sensitivity / drug effects*
Ethanol / pharmacology*
Female
Humans
Male
Photic Stimulation / methods
Psychophysics / methods
Reference Values
Visual Pathways / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
P30-EY01792/EY/NEI NIH HHS; R01 EY019651/EY/NEI NIH HHS; R01-AA013746/AA/NIAAA NIH HHS; R01-EY019651/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol
Comments/Corrections

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