| Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects. | |
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MedLine Citation:
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PMID: 11316647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of tetracaine aerosol inhalation, a local anesthetic, on lung volume decrements, rapid shallow breathing, and subjective symptoms of breathing discomfort induced by the acute inhalation of 0.30 ppm ozone for 65 min in 22 ozone-sensitive healthy human subjects. After 50 min of ozone inhalation FEV(1) was reduced 24%, breathing frequency was increased 40%, tidal volume was decreased 31%, and total subjective symptom score was increased (71.2, compared with 3.8 for filtered air exposure). Inhalation of tetracaine aerosol resulted in marked reductions in ozone-induced subjective symptoms of throat tickle and/or irritation (92.1%), cough (78.5%), shortness of breath (72.5%), and pain on deep inspiration (69.4%). In contrast, inhalation of tetracaine aerosol (mass median aerodynamic diameter of 3.52 microm with a geometric standard deviation of 1.92) resulted in only minor and inconsistent rectification of FEV(1) decrements (5.0%) and breathing frequency (-3.8%) that was not significantly different from that produced by saline aerosol alone (FEV(1), 5.1% and breathing frequency, -2.7%). Our data are consistent with afferent endings located within the large conducting airways of the tracheobronchial tree being primarily responsible for ozone-induced subjective symptoms and provides strong evidence that ozone-induced inhibition of maximal inspiratory effort is not dependent on conscious sensations of inspiratory discomfort. |
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Authors:
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E S Schelegle; M W Eldridge; C E Cross; W F Walby; W C Adams |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 163 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-24 Completed Date: 2001-06-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1121-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA. esschelegle@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Adult Afferent Pathways / drug effects* Analysis of Variance Anesthetics, Local / pharmacology* Female Humans Linear Models Male Ozone / adverse effects* Respiration / drug effects Respiratory Hypersensitivity / chemically induced*, physiopathology Respiratory Mechanics / drug effects Respiratory System / drug effects, innervation* Single-Blind Method Tetracaine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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ES-06791/ES/NIEHS NIH HHS; HL-47628/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 10028-15-6/Ozone; 94-24-6/Tetracaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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