Document Detail

Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects.
MedLine Citation:
PMID:  11316647     Owner:  NLM     Status:  MEDLINE    
We examined the effect of tetracaine aerosol inhalation, a local anesthetic, on lung volume decrements, rapid shallow breathing, and subjective symptoms of breathing discomfort induced by the acute inhalation of 0.30 ppm ozone for 65 min in 22 ozone-sensitive healthy human subjects. After 50 min of ozone inhalation FEV(1) was reduced 24%, breathing frequency was increased 40%, tidal volume was decreased 31%, and total subjective symptom score was increased (71.2, compared with 3.8 for filtered air exposure). Inhalation of tetracaine aerosol resulted in marked reductions in ozone-induced subjective symptoms of throat tickle and/or irritation (92.1%), cough (78.5%), shortness of breath (72.5%), and pain on deep inspiration (69.4%). In contrast, inhalation of tetracaine aerosol (mass median aerodynamic diameter of 3.52 microm with a geometric standard deviation of 1.92) resulted in only minor and inconsistent rectification of FEV(1) decrements (5.0%) and breathing frequency (-3.8%) that was not significantly different from that produced by saline aerosol alone (FEV(1), 5.1% and breathing frequency, -2.7%). Our data are consistent with afferent endings located within the large conducting airways of the tracheobronchial tree being primarily responsible for ozone-induced subjective symptoms and provides strong evidence that ozone-induced inhibition of maximal inspiratory effort is not dependent on conscious sensations of inspiratory discomfort.
E S Schelegle; M W Eldridge; C E Cross; W F Walby; W C Adams
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  163     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-24     Completed Date:  2001-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1121-7     Citation Subset:  AIM; IM    
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA.
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MeSH Terms
Administration, Inhalation
Afferent Pathways / drug effects*
Analysis of Variance
Anesthetics, Local / pharmacology*
Linear Models
Ozone / adverse effects*
Respiration / drug effects
Respiratory Hypersensitivity / chemically induced*,  physiopathology
Respiratory Mechanics / drug effects
Respiratory System / drug effects,  innervation*
Single-Blind Method
Tetracaine / pharmacology
Grant Support
Reg. No./Substance:
0/Anesthetics, Local; 10028-15-6/Ozone; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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