| Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation. | |
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MedLine Citation:
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PMID: 23349454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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During exercise, an old age-associated inability to increase vascular resistance within the intra-abdominal adipose tissue (AT) may compromise the ability to redistribute blood flow. We tested the hypotheses that 1) there would be an elevated perfusion of AT during exercise with old age that was associated with diminished vasoconstrictor responses of adipose resistance arteries, and 2) chronic exercise training would mitigate age-associated alterations in AT blood flow and vascular function. Young (6 mo; n=40) and old (24 mo; n=28) male Fischer 344 rats were divided into young sedentary (YSed), old sedentary (OSed), young exercise-trained (YET) or old exercise-trained (OET) groups, where training consisted of 10-12 weeks of treadmill exercise. In vivo blood flow at rest and during exercise and in vitro α-adrenergic and myogenic vasoconstrictor responses in resistance arteries from AT were measured in all groups. In response to exercise there was a directionally opposite change in AT blood flow in OSed group (~150% increase) and YSed (~ 55% decrease) versus resting values. Both α-adrenergic and myogenic vasoconstriction were diminished in OSed versus YSed AT resistance arteries. Exercise training resulted in a similar AT hyperemic response between age groups during exercise (YET, 9.9 ± 0.5; OET, 8.1 ± 0.9 ml/min/100 g) and was associated with enhanced myogenic and α-adrenergic vasoconstriction of AT resistance arteries from the OET group relative to OSed. These results indicate that there is an inability to increase vascular resistance in AT during exercise with old age due, in part, to a diminished vasoconstriction of AT arteries. |
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Authors:
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Robert T Davis; John N Stabley; James Michael Dominguez; Michael W Ramsey; Danielle Jillian McCullough; Lisa A Lesniewski; Micheal D Delp; Bradley Jon Behnke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Florida. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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