Document Detail

Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension.
MedLine Citation:
PMID:  17596529     Owner:  NLM     Status:  MEDLINE    
The tetradecythioacetic acid (TTA) is a modified fatty acid known to exhibit pleiotropic effects. First, we compared the effect of TTA on the blood pressure in spontaneously hypertensive rats (SHR) with two-kidney, one-clip (2K1C)-hypertensive rats. Second, we examined mechanisms involved in the blood pressure reduction. TTA had minor effect on systolic blood pressure (SBP) in young SHR up to 8 wk of age. In 2K1C we confirmed the blood pressure-lowering effect of TTA (SBP: 173 +/- 4 before vs. 138 +/- 3 mmHg after TTA, P < 0.001). No effect on SBP was seen in Wistar-Kyoto rat (WKY) controls. Plasma renin activity (PRA) was low in SHR and WKY controls and TTA did not change it. PRA decreased from 22.9 +/- 1.3 to 16.2 +/- 2.2 (P = 0.02) in 2K1C. Plasma ANG II concentration declined from 101 +/- 3 to 81 +/- 5 fmol/l after TTA treatment (P = 0.005). In the clipped kidney, tissue ANG I concentration decreased from 933 +/- 68 to 518 +/- 60 fmol/g tissue (P = 0.001), and ANG II decreased from 527 +/- 38 to 149 +/- 21 fmol/g tissue (P < 0.001) after TTA treatment. In the nonclipped kidney, TTA did not change ANG I and moderately reduced ANG II levels. The renal blood flow response to injection of ANG II into the nonclipped kidney was blunted compared with controls and normalized with TTA treatment (10 +/- 2 before vs. 20 +/- 2%, P < 0.001). The results indicate that TTA downregulates the renin-angiotensin system in high renin animals but has no effect in low renin models.
Liliana Monica Bivol; Rolf Kristian Berge; Bjarne Magnus Iversen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-27
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  293     ISSN:  1931-857X     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-29     Revised Date:  2011-04-28    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F839-45     Citation Subset:  IM    
Renal Research Group, Institute of Medicine, University of Bergen, Bergen, Norway.
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MeSH Terms
Angiotensin I / metabolism
Angiotensin II / blood
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects*
Hypertension / drug therapy*,  pathology
Kidney / drug effects,  metabolism,  pathology,  surgery*
Rats, Inbred WKY
Renal Circulation / drug effects
Renin-Angiotensin System / drug effects*
Sulfhydryl Compounds / pharmacology*
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Sulfhydryl Compounds; 0/tetradecythioacetic acid; 11128-99-7/Angiotensin II; 9041-90-1/Angiotensin I

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