Document Detail

Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex.
MedLine Citation:
PMID:  2709017     Owner:  NLM     Status:  MEDLINE    
Microdialysis was used to assess extracellular dopamine in striatum, nucleus accumbens, and medial frontal cortex of unanesthetized rats both under resting conditions and in response to intermittent tail-shock stress. The dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid also were measured. The resting extracellular concentration of dopamine was estimated to be approximately 10 nM in striatum, 11 nM in nucleus accumbens, and 3 nM in medial frontal cortex. In contrast, the resting extracellular levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were in the low micromolar range. Intermittent tail-shock stress increased extracellular dopamine relative to baseline by 25% in striatum, 39% in nucleus accumbens, and 95% in medial frontal cortex. 3,4-Dihydroxyphenylacetic acid and homovanillic acid also were generally increased by stress, although there was a great deal of variability in these responses. These data provide direct in vivo evidence for the global activation of dopaminergic systems by stress and support the concept that there exist regional variations in the regulation of dopamine release.
E D Abercrombie; K A Keefe; D S DiFrischia; M J Zigmond
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  52     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1655-8     Citation Subset:  IM    
Department of Behavioral Neuroscience, University of Pittsburgh, Pennsylvania 15260.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Corpus Striatum / secretion*
Dopamine / secretion*
Extracellular Space / metabolism
Frontal Lobe / secretion*
Homovanillic Acid / metabolism
Nucleus Accumbens / secretion*
Rats, Inbred Strains
Septal Nuclei / secretion*
Stress, Physiological / physiopathology*
Grant Support
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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