Document Detail


Differential effect of some antiarrhythmic drugs in right- or left-sided aconitine-induced experimental atrial arrhythmias.
MedLine Citation:
PMID:  3586773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The differential effect of different antiarrhythmic agents, quinidine, propranolol, verapamil and sotalol was studied on right- and left-sided aconitine-induced atrial arrhythmias in dogs. In control experiments the time required for the reversion of right aconitine-induced atrial arrhythmias to normal sinus rhythm was higher as compared to left-sided aconitine-induced atrial arrhythmias. All the drugs studied were effective in reverting atrial arrhythmias to normal sinus rhythm, and doses required for suppression of the right atrial arrhythmias as compared to the left atrial arrhythmias were significantly higher in the case of quinidine, sotalol and verapamil, but not in the case of propranolol. The differential antiarrhythmic effect of these drugs in atrial arrhythmias is discussed.
Authors:
C S Gautam; R Lal; P Pandhi; P L Sharma
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  9     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  91-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aconitine
Animals
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / chemically induced,  drug therapy*
Atrial Flutter / chemically induced,  drug therapy*
Dogs
Female
Male
Propranolol / therapeutic use
Quinidine / therapeutic use
Sotalol / therapeutic use
Verapamil / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 302-27-2/Aconitine; 3930-20-9/Sotalol; 52-53-9/Verapamil; 525-66-6/Propranolol; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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