Document Detail

Differential effect of recruitment maneuvres on pulmonary blood flow and oxygenation during HFOV in preterm lambs.
MedLine Citation:
PMID:  18535129     Owner:  NLM     Status:  MEDLINE    
The effects of lung volume recruitment manouvres on pulmonary blood flow (PBF) during high-frequency oscillatory ventilation (HFOV) in preterm neonates are unknown. Since increased airway pressure adversely affects PBF, we compared the effects of two HFOV recruitment strategies on PBF and oxygenation index (OI). Preterm lambs (128+/-1 day gestation; term approximately 150 days) were anesthetized and ventilated using HFOV (10 Hz, 33% tI) with a mean airway pressure (Pao) of 15 cmH2O. Lung volume was recruited by either increasing Pao to 25 cmH2O for 1 min, repeated five times at 5-min intervals (Sigh group; n=5) or stepwise (5 cmH2O) changes in Pao at 5-min intervals incrementing up to 30 cmH2O then decrementing back to 15 cmH2O (Ramp group; n=6). Controls (n=5) received constant HFOV at 15 cmH2O. PBF progressively decreased (by 45+/-4%) and OI increased (by 15+/-6%, indicating reduced oxygenation) in controls during HFOV, which was similar to the changes observed in the Sigh group of lambs. In the Ramp group, PBF fell (by 54+/-10%) as airway pressure increased (r2=0.99), although the PBF did not increase again as the Pao was subsequently reduced. The OI decreased (by 47+/-9%), reflecting improved oxygenation at high Pao levels during HFOV in the Ramp group. However, high Pao restored retrograde PBF during diastole in four of six lambs, indicating the restoration of right-to-left shunting through the ductus arteriosus. Thus the choice of volume recruitment maneuvre influences the magnitude of change in OI and PBF that occurs during HFOV. Despite significantly improving OI, the ramp recruitment approach causes sustained changes in PBF.
Graeme R Polglase; Timothy J M Moss; Ilias Nitsos; Beth J Allison; J Jane Pillow; Stuart B Hooper
Related Documents :
7842219 - Pulmonary surfactant maintains patency of conducting airways in the rat.
24831499 - Mechanical influences in progressive intervertebral disc degeneration.
8148579 - Randomized placebo-controlled study on the characteristics and duration of action of su...
3307569 - Lung function in prematurely delivered rabbits treated with a synthetic surfactant.
8078029 - Evaluation of lung function changes before and after surfactant application during arti...
15552129 - High-pressure pulsatile lavage causes soft tissue damage.
9535459 - Inhaled nitric oxide is not a myocardial depressant in a porcine model of heart failure.
21389529 - Dft study of structure stability and elasticity of wadsleyite ii.
670009 - Effect of parenchymal shear modulus and lung volume on bronchial pressure-diameter beha...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-05
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  105     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-05     Completed Date:  2008-10-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-10     Citation Subset:  IM    
School of Women's and Infants Health, M094 The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid-Base Equilibrium / physiology
Animals, Newborn / physiology*
Blood Gas Analysis
Blood Pressure / physiology
Chest Wall Oscillation*
Lung / metabolism*
Oxygen / blood*
Pulmonary Circulation / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genes, exercise, growth, and the sedentary, obese child.
Next Document:  Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammator...