| Differential effect of nerve fiber structure on block by local anesthetic. | |
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MedLine Citation:
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PMID: 4025865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of conduction block by lidocaine 0.3 mmol/l (8.1 mg/dl) in several successive lengths of individual afferent axons of rabbit was compared. The conduction velocity of the axons was either "slow," "intermediate" (1.3-4 m/s), or "fast." The "intermediate" group showed a higher incidence of proximal acceleration of conduction (P less than 0.001) and a greater incidence of block (P less than 0.001) than the "slow" and "fast" fiber groups. The results were interpreted as indicating that the fibers of the "intermediate" group had an unmyelinated peripheral and a myelinated proximal length, with a junctional heminodal region that was the seat of the high sensitivity to block. The potential clinical significance of the observation is discussed in terms of the known distribution of heminodes in the peripheral nervous system. |
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Authors:
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B R Fink; A M Cairns |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 63 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-08-27 Completed Date: 1985-08-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 157-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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pharmacology* Animals Axons / drug effects Ganglia, Parasympathetic / drug effects Ganglia, Sympathetic / drug effects Lidocaine / pharmacology Nerve Block* Nerve Fibers / anatomy & histology, drug effects* Nerve Fibers, Myelinated / drug effects Neural Conduction / drug effects Rabbits Vagus Nerve / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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CA 33522/CA/NCI NIH HHS; GM 31710/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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