| Differential effect of lithium treatment on fenfluramine-induced decreases in food intake and locomotor activity in rats. | |
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MedLine Citation:
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PMID: 22282367 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Administration of fenfluramine to rats decreased 1-h food intake and locomotor activity. Short-term (2-6 days) but not long-term (21-25 days) lithium treatment potentiated fenfluramine-induced suppression of food intake. However, neither short-term nor long-term lithium treatment had any significant effect on fenfluramine-induced suppression of locomotor activity. These findings demonstrate a differential effect of lithium treatment on fenfluramine-induced suppression of food intake and locomotor activity. Furthermore, these findings are consistent with results from several other animal and clinical studies demonstrating a differential effect of lithium treatment on two different serotonin-mediated functions. |
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Authors:
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C S Aulakh; J Zohar; K M Wozniak; J L Hill; D L Murphy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of psychopharmacology (Oxford, England) Volume: 5 ISSN: 0269-8811 ISO Abbreviation: J. Psychopharmacol. (Oxford) Publication Date: 1991 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907828 Medline TA: J Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 149-54 Citation Subset: - |
Affiliation:
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Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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