Document Detail


Differential effect of lithium treatment on fenfluramine-induced decreases in food intake and locomotor activity in rats.
MedLine Citation:
PMID:  22282367     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Administration of fenfluramine to rats decreased 1-h food intake and locomotor activity. Short-term (2-6 days) but not long-term (21-25 days) lithium treatment potentiated fenfluramine-induced suppression of food intake. However, neither short-term nor long-term lithium treatment had any significant effect on fenfluramine-induced suppression of locomotor activity. These findings demonstrate a differential effect of lithium treatment on fenfluramine-induced suppression of food intake and locomotor activity. Furthermore, these findings are consistent with results from several other animal and clinical studies demonstrating a differential effect of lithium treatment on two different serotonin-mediated functions.
Authors:
C S Aulakh; J Zohar; K M Wozniak; J L Hill; D L Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  5     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  1991 Jan 
Date Detail:
Created Date:  2012-01-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  -    
Affiliation:
Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health.
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