Document Detail

Differential effect of dietary salt on renal growth in Dahl salt-sensitive and salt-resistant rats.
MedLine Citation:
PMID:  2914734     Owner:  NLM     Status:  MEDLINE    
A high salt diet has been shown to increase renal mass of intact rats, although the mechanism by which this occurs has not been investigated. We used Dahl rats that are sensitive (DS) or resistant (DR) to the hypertensinogenic effect of salt to examine changes in renal size and composition caused by a high salt diet. Renal index, deoxyribonucleic acid (DNA), protein, water content, protein/DNA ratio, and cell number and size were measured in age-matched DR and DS on a high salt diet for 7, 14, or 28 days. The results were compared with those obtained from respective rats on a low salt diet. High salt diet elevated renal index and protein in DR and DS rats at each time point. After 7 days of a high salt diet, DNA increased in DS only. Protein/DNA ratio was progressively decreased by a high salt diet in DS and remained unchanged in DR rats. Cell number was increased 35% in DS versus only 13% in DR rats at 4 weeks. Cell size decreased 24% in DS and only 11% in DR rats. These results indicate that renal growth due to hyperplasia accompanies ingestion of a high salt diet in both DR and DS rats, but the rate of growth and the mechanism through which it occurs differ between strains. This difference may be important in delineating salt sensitivity and future development of hypertension.
C P McCormick; A L Rauch; V M Buckalew
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  13     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-7     Citation Subset:  IM    
Department of Physiology/Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
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MeSH Terms
Blood Pressure / drug effects
Body Weight / drug effects
Cell Count
DNA / analysis
Kidney / analysis,  drug effects*,  pathology
Proteins / analysis
Sodium Chloride / administration & dosage*
Reg. No./Substance:
0/Proteins; 7647-14-5/Sodium Chloride; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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