Document Detail

Differential effect of d-fenfluramine and metergoline on food intake in human subjects.
MedLine Citation:
PMID:  3250335     Owner:  NLM     Status:  MEDLINE    
This study investigated the effect of the 5-HT receptor blocker metergoline (MTG) on d-fenfluramine (d-FF)-induced reduction of food intake in 13 normal male human volunteer subjects. Food was freely available for 2h, 4h after drug administration, from a four-channel automated food dispenser. d-FF (30 mg) reduced total food intake and exerted a marked effect on non-sweet food which was attenuated by the addition of MTG (4 mg). d-FF had less effect on sweet-tasting food while intake of sweet food was significantly increased by MTG. There was a significant interaction between d-FF and MTG on sweet-tasting foods. No effect on MTG was observed on d-FF-induced changes in ratings of hunger.
E Goodall; T Silverstone
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Appetite     Volume:  11     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-06-29     Completed Date:  1989-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  215-28     Citation Subset:  IM    
Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital, London.
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MeSH Terms
Anorexia / chemically induced
Appetite / drug effects
Eating / drug effects*
Ergolines / pharmacology*
Fenfluramine / pharmacology*
Metergoline / pharmacology*
Satiety Response / drug effects
Serotonin Antagonists
Time Factors
Reg. No./Substance:
0/Ergolines; 0/Serotonin Antagonists; 17692-51-2/Metergoline; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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