Document Detail

Differential effect of a chemical algogen on two nociceptive thresholds.
MedLine Citation:
PMID:  2388947     Owner:  NLM     Status:  MEDLINE    
Several previous studies have demonstrated that, depending upon the behavioral test used, counterirritation can elicit hypoalgesia at body sites distant from the second painful stimulus. Behavioral responses were elicited in the rat by increasing calibrated pressure on a hindpaw (Randall-Selitto test) and were studied before and after a subcutaneous formalin injection. The vocalization threshold to the pressure was clearly increased after injection of the algogenic solution either in the forepaw or in the cheek, whereas the struggle threshold was unchanged. These results are discussed in terms of the ability of an "active" localized noxious stimulation to induce heterotopic hypoalgesic effects dependent on the level of integration of the "passive" pain behavior tested.
B Calvino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  47     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  907-10     Citation Subset:  IM    
Laboratoire de Physiopharmacologie du Système Nerveux, INSERM U161, Paris, France.
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MeSH Terms
Arousal / physiology*
Attention / physiology*
Chemoreceptor Cells / physiology*
Nociceptors / physiology*
Rats, Inbred Strains
Reaction Time / physiology
Sensory Thresholds / physiology
Reg. No./Substance:

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