| Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytes. | |
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MedLine Citation:
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PMID: 16939707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Chinese medicine Rhizoma coptidis (RC) is well established in the treatment of common dermatological disorders although the mechanism of its' anti-inflammatory effects have previously remained elusive. We stimulated an inflammatory state in human keratinocyte cultures using TNF-alpha in the presence of RC extract (RCE) and berberine, to identify the dose-dependent anti-inflammatory role of these compounds. Control data demonstrates significant translocation of NFkappaB into the nucleus after stimulation with TNF-alpha. This translocation can be inhibited, and hence anti-inflammatory effects inferred, by RCE but not by berberine. We conclude that in dermatological disorders berberine exerts its anti-inflammatory effects by inhibiting signal transduction pathways other than the NFkappaB dependent pathway, while the RCE complex acts partially by blocking the NFkappaB dependent pathway. Rhizoma coptidis extract therefore appears to be a potent inhibitor of TNF-alpha induced inflammation in dermatological conditions. |
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Authors:
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Ronny Enk; Robert Ehehalt; Jane E Graham; Angelika Bierhaus; Andrew Remppis; Henry Johannes Greten |
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Publication Detail:
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Type: Journal Article Date: 2006-07-14 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 109 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 170-5 Citation Subset: IM |
Affiliation:
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Medizinische Klinik III, Universität Heidelberg, Germany. ronny.enk@dgtcm.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal* Berberine / pharmacology* Cells, Cultured Dose-Response Relationship, Drug Drugs, Chinese Herbal / pharmacology* Fluorescent Antibody Technique Humans Keratinocytes / drug effects, metabolism* NF-kappa B / metabolism* Phosphorylation / drug effects Transcription Factor RelA / metabolism Translocation, Genetic / drug effects Tumor Necrosis Factor-alpha / antagonists & inhibitors*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Coptidis rhizoma extract; 0/Drugs, Chinese Herbal; 0/NF-kappa B; 0/Transcription Factor RelA; 0/Tumor Necrosis Factor-alpha; 2086-83-1/Berberine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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