Document Detail

Differential distribution of transforming growth factor beta and receptors in the hyper or hypoproliferative gastric mucosa of developing and adult rats.
MedLine Citation:
PMID:  17149687     Owner:  NLM     Status:  MEDLINE    
Transforming growth factor beta (TGFbeta) isoforms are known for their antiproliferative effect on epithelial cells in vitro, but the role of each isoform in vivo is poorly understood, mainly when non-pathological conditions are considered. We correlated the presence and distribution of isoforms and receptors to physiological changes in gastric cell proliferation in developing and adult rats. We used fasting to induce either the hyper (14-day-old pups) or hypoproliferation (60-day-old rats) of the gastric epithelium. In 14-d-old pups fasting reduced only TGFbeta3 labelling in the gland. Conversely, in 60-d-old rats there was an increase of TGFbeta1 and TGFbeta3 immunolabelled cells. Receptors were detected at both ages. Therefore, the changes induced by fasting in the constitutive TGFbeta expression can be correlated to the differential epithelial proliferation in the stomach of developing and adult rats. These results suggest that one of the functional roles of TGFbeta in vivo is to locally regulate cell proliferation.
E P Alvares; L R Jordão; P Gama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histology and histopathology     Volume:  22     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-06     Completed Date:  2006-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
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MeSH Terms
Animals, Suckling
Cell Proliferation
Food Deprivation
Gastric Mucosa / cytology,  growth & development,  metabolism*
Immunoenzyme Techniques
Protein Isoforms
Rats, Wistar
Receptors, Transforming Growth Factor beta / metabolism*
Transforming Growth Factor beta / metabolism*
Reg. No./Substance:
0/Protein Isoforms; 0/Receptors, Transforming Growth Factor beta; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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