Document Detail

Differential distribution of mechanosensitive nonselective cation channels in systemic and pulmonary arterial myocytes of rabbits.
MedLine Citation:
PMID:  16733370     Owner:  NLM     Status:  MEDLINE    
The mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-attached condition, a negative pressure via patch pipettes commonly activated NSC(MS) with weak voltage dependence. The threshold pressure for activation was lower, and the density of NSC(MS) was higher in the pulmonary than the systemic arteries. When the pulmonary arteries were divided into small-diameter (outer diameter, OD < 0.5 mm) and large-diameter (OD > 1.5 mm) arteries, the low threshold and high density of NSC(MS) were observed only in small-diameter ones. No such difference was observed between the small- and large-diameter coronary arteries. The higher stretch sensitivity and denser functional expression of NSC(MS) in small pulmonary arteries might suggest an adaptive tuning for the relatively low pulmonary blood pressure in vivo.
Kyung Sun Park; Hyang Ae Lee; Kee Hyun Earm; Jae Hong Ko; Yung E Earm; Sung Joon Kim
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-29
Journal Detail:
Title:  Journal of vascular research     Volume:  43     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, Korea.
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MeSH Terms
Coronary Vessels / anatomy & histology,  physiology*
Ion Channel Gating
Ion Channels / physiology*
Mechanoreceptors / physiology*
Mechanotransduction, Cellular
Membrane Potentials
Mesenteric Arteries / anatomy & histology,  physiology*
Muscle Contraction
Myocytes, Smooth Muscle / physiology
Patch-Clamp Techniques
Pulmonary Artery / anatomy & histology,  physiology*
Reg. No./Substance:
0/Cations; 0/Ion Channels

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