| Differential distribution of ferulic acid to the major plasma constituents in relation to its potential as an antioxidant. | |
| | |
MedLine Citation:
|
PMID: 8687419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hydroxycinnamates, intermediates in the phenylpropanoid synthetic pathway, are effective in enhancing the resistance of low-density lipoprotein (LDL) to oxidation in the order caffeic acid > ferulic acid > p-coumaric acid. It is unclear whether the mode of action of ferulic acid as an antioxidant is based on its activities in the aqueous or the lipophilic phase. Partitioning of 14C-labelled ferulic acid into plasma and its components, LDL and the albumin-rich fractions, has been studied under conditions of maximum aqueous solubility. The majority of ferulic acid associates with the albumin-rich fraction of the plasma, although a proportion is also found to partition between the LDL and aqueous phases; however, ferulic acid does not associate with the lipid portion of the LDL particle, suggesting that it exerts its antioxidant properties from the aqueous phase. This is of particular interest since the results demonstrate that ferulic acid is a more effective antioxidant against LDL oxidation than the hydrophilic antioxidant ascorbic acid. |
| | |
Authors:
|
C Castelluccio; G P Bolwell; C Gerrish; C Rice-Evans |
Related Documents
:
|
9808609 - Mechanism of action of fibrates on lipid and lipoprotein metabolism. 178359 - Characterization of the plasma lipoproteins and apoproteins of the erythrocebus patas m... 11448569 - Influence of apolipoprotein-e phenotypes on postprandial lipoprotein metabolism after t... 8136359 - Hydration and localization of diacylglycerol in the insect lipoprotein lipophorin. a 13... 6874679 - The role of lipoprotein lipase in the metabolism of triglyceride-rich lipoproteins by m... 16123359 - Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men. 9808609 - Mechanism of action of fibrates on lipid and lipoprotein metabolism. 18421699 - Exploring the high-mass components of humic acid by laser desorption ionization mass sp... 23327299 - Fatty acid composition of lipids in pot marigold (calendula officinalis l.) seed genoty... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Biochemical journal Volume: 316 ( Pt 2) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1996 Jun |
Date Detail:
|
Created Date: 1996-08-20 Completed Date: 1996-08-20 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 691-4 Citation Subset: IM |
Affiliation:
|
Free Radical Research Group, UMDS-Guy's Hospital, London, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antioxidants
/
pharmacology* Ascorbic Acid / pharmacology Cinnamates / pharmacology Coumaric Acids / blood*, pharmacology* Humans Lipid Peroxidation Lipoproteins, LDL / blood, metabolism* Liposomes / metabolism Phosphatidylcholines / metabolism Solubility |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Cinnamates; 0/Coumaric Acids; 0/Lipoproteins, LDL; 0/Liposomes; 0/Phosphatidylcholines; 1135-24-6/ferulic acid; 50-81-7/Ascorbic Acid; 621-82-9/cinnamic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enzymic and molecular characterization of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase fr...
Next Document: Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chr...