Document Detail

Differential distribution of Fc gamma RIIIa in normal human tissues and co-localization with DAF and fibrillin-1: implications for immunological microenvironments.
MedLine Citation:
PMID:  9708187     Owner:  NLM     Status:  MEDLINE    
Fc gamma RIIIa is a cytokine-inducible IgG Fc receptor implicated in the activation of macrophages by immune complexes. Differential expression of Fc gamma RIIIa by macrophages in different tissues may therefore modulate local immune responsiveness. Fc gamma RIIIa expression in normal human tissues was assessed semiquantitatively using microdensitometry. Synovial intimal, serosal, alveolar, salivary gland and placental macrophages, Kupffer cells, and macrophages in mechanically stressed dermis expressed high levels of Fc gamma RIIIa. Less consistent expression was seen in skeletal muscle and lymphoid organs. No significant expression was observed in brain, thyroid, spine, intestine, myocardium, prostate, uterus, flexor forearm dermis, uterus, or kidney. Staining for Fc gamma RIII was also observed on extracellular matrix, and co-localized with both complement decay-accelerating factor and fibrillin-1. It is proposed that differential levels of both cellular and extracellular Fc gamma RIIIa, by modulating the response to immune complexes, may contribute to relative tissue susceptibility to infection and autoimmune disease.
A Bhatia; S Blades; G Cambridge; J C Edwards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  94     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  56-63     Citation Subset:  IM    
Rheumatology Unit, University College London, UK.
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MeSH Terms
Antigens, CD55 / metabolism*
Extracellular Matrix / immunology
Extracellular Matrix Proteins / metabolism*
Fluorescent Antibody Technique
Immunoenzyme Techniques
Macrophages / immunology*
Microfilament Proteins / metabolism*
Receptors, IgG / metabolism*
Reg. No./Substance:
0/Antigens, CD55; 0/Extracellular Matrix Proteins; 0/Microfilament Proteins; 0/Receptors, IgG; 0/fibrillin

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