Document Detail

Differential display PCR reveals increased expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase by lithium.
MedLine Citation:
PMID:  8647287     Owner:  NLM     Status:  MEDLINE    
Differential display PCR was used to study the effects of lithium on gene expression. Four candidate genes were isolated and verified by Northern hybridization after 1 week treatment of C6 glioma cells with therapeutically relevant concentrations of LiCl (1 mM). Sequencing analysis revealed three previously unidentified cDNA fragments in addition to a sequence with 99% homology with the cDNA for 2',3'-cyclic nucleotide 3'-phosphodiesterase type II (CNPaseII). Since CNPaseII is important in myelinogenesis and possibly neuronal growth and repair, the present findings suggest that lithium treatment may regulate these processes.
J F Wang; L T Young
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  386     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-25     Completed Date:  1996-07-25     Revised Date:  2012-04-16    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  225-9     Citation Subset:  IM    
Department of Psychiatry, McMaster University, Hamilton, Ont., Canada.
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MeSH Terms
2',3'-Cyclic-Nucleotide Phosphodiesterases / genetics*
Base Sequence
Carbamazepine / pharmacology
Gene Expression / drug effects*
Lithium Chloride / pharmacology*
Molecular Sequence Data
Neuroglia / drug effects,  metabolism
Phosphoric Diester Hydrolases*
Polymerase Chain Reaction
Sodium Chloride / pharmacology
Tumor Cells, Cultured
Valproic Acid / pharmacology
Reg. No./Substance:
0/Oligodeoxyribonucleotides; 298-46-4/Carbamazepine; 7447-41-8/Lithium Chloride; 7647-14-5/Sodium Chloride; 99-66-1/Valproic Acid; EC 3.1.4.-/2',3'-Cyclic-Nucleotide Phosphodiesterases; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC',3'-cyclic nucleotide 3'-phosphodiesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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