| Differential display PCR reveals increased expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase by lithium. | |
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MedLine Citation:
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PMID: 8647287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differential display PCR was used to study the effects of lithium on gene expression. Four candidate genes were isolated and verified by Northern hybridization after 1 week treatment of C6 glioma cells with therapeutically relevant concentrations of LiCl (1 mM). Sequencing analysis revealed three previously unidentified cDNA fragments in addition to a sequence with 99% homology with the cDNA for 2',3'-cyclic nucleotide 3'-phosphodiesterase type II (CNPaseII). Since CNPaseII is important in myelinogenesis and possibly neuronal growth and repair, the present findings suggest that lithium treatment may regulate these processes. |
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Authors:
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J F Wang; L T Young |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 386 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-07-25 Completed Date: 1996-07-25 Revised Date: 2012-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, McMaster University, Hamilton, Ont., Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2',3'-Cyclic-Nucleotide Phosphodiesterases
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genetics* Base Sequence Carbamazepine / pharmacology Gene Expression / drug effects* Humans Lithium Chloride / pharmacology* Molecular Sequence Data Neuroglia / drug effects, metabolism Oligodeoxyribonucleotides Phosphoric Diester Hydrolases* Polymerase Chain Reaction Sodium Chloride / pharmacology Tumor Cells, Cultured Valproic Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Oligodeoxyribonucleotides; 298-46-4/Carbamazepine; 7447-41-8/Lithium Chloride; 7647-14-5/Sodium Chloride; 99-66-1/Valproic Acid; EC 3.1.4.-/2',3'-Cyclic-Nucleotide Phosphodiesterases; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC 3.1.4.37/2',3'-cyclic nucleotide 3'-phosphodiesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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