|Differential diagnosis of retinal vasculitis.|
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|PMID: 20404987 Owner: NLM Status: PubMed-not-MEDLINE|
|Retinal vaculitis is a sight-threatening inflammatory eye condition that involves the retinal vessels. Detection of retinal vasculitis is made clinically, and confirmed with the help of fundus fluorescein angiography. Active vascular disease is characterized by exudates around retinal vessels resulting in white sheathing or cuffing of the affected vessels. In this review, a practical approach to the diagnosis of retinal vasculitis is discussed based on ophthalmoscopic and fundus fluorescein angiographic findings.|
|Ahmed M Abu El-Asrar; Carl P Herbort; Khalid F Tabbara|
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|Type: Journal Article|
|Title: Middle East African journal of ophthalmology Volume: 16 ISSN: 0975-1599 ISO Abbreviation: Middle East Afr J Ophthalmol Publication Date: 2009 Oct|
|Created Date: 2010-04-20 Completed Date: 2011-07-14 Revised Date: 2013-05-29|
Medline Journal Info:
|Nlm Unique ID: 101521797 Medline TA: Middle East Afr J Ophthalmol Country: India|
|Languages: eng Pagination: 202-18 Citation Subset: -|
|Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.|
|APA/MLA Format Download EndNote Download BibTex|
Journal ID (nlm-ta): Middle East Afr J Ophthalmol
Journal ID (publisher-id): MEAJO
Publisher: Medknow Publications, India
? Middle East African Journal of Ophthalmology
Print publication date: Season: Oct?Dec Year: 2009
Volume: 16 Issue: 4
First Page: 202 Last Page: 218
PubMed Id: 20404987
Publisher Id: MEAJO-16-202
|Differential Diagnosis of Retinal Vasculitis|
|Ahmed M. Abu El-AsrarAF0001|
|Carl P. Herbort1|
|Khalid F. Tabbara2|
|Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
1Inflammatory and Retinal Eye Diseases, Center for Ophthalmic Specialized Care and University of Lausanne, Lausanne, Switzerland
2The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia
|Correspondence: Corresponding Author:Prof. Ahmed M. Abu El-Asrar, Department of Ophthalmology King Abdulaziz University Hospital Airport Road, P.O. Box 245, Riyadh 11411, Saudi Arabia. E-mail: firstname.lastname@example.org
Retinal vasculitis is a sight-threatening inflammatory eye condition that involves the retinal vessels. It may occur as an isolated idiopathic condition, as a complication of infective or neoplastic disorders, or in association with systemic inflammatory disease1 [Table 1].
Detection of retinal vasculitis is made clinically, and confirmed with the help of fundus fluorescein angiography. Active vascular disease is characterized by exudates around retinal vessels resulting in white sheathing or cuffing of the affected vessels, which may be segmental (skip lesions) or confluent [Figure 1].
Although retinal arterioles or branch retinal arteries may be involved in secondary systemic vasculitides such as systemic lupus erythematosus (SLE), as well as primary systemic vasculitides such as Wegener's granulomatosus, polyarteritis nodosa, Churg-Strauss syndrome or cryoglobulinemia,2 this usually leads to occlusion by microthrombosis, and intraocular inflammation is often not a feature of these diseases.3, 4 Therefore, this type of occlusive vasculopathy should be recognized and distinguished from other conditions characterized by active vascular sheathing or cuffing with perivascular inflammatory infiltrate.
Retinal vasculitis results in leakage leading to retinal swelling, exudation, and macular edema. Cystoid macular edema is a significant contributing factor for poor vision in retinal vasculitis. Cystoid macular edema, when adequately treated with immunosuppressive therapy, is associated with a good prognosis.5 Occlusive retinal vasculitis affecting the retinal arterioles may cause cotton-wool spots representing microinfarcts of the retina. Central retinal artery and branch retinal artery occlusions are also reported in patients with retinal vasculitis.6?12 Occlusive periphlebitis can cause retinal edema, intraretinal hemorrhages, and hemorrhagic infarction of the retina. Poor visual outcome in some patients with retinal vasculitis, despite adequate therapy, may be explained by the presence of macular ischemia.5, 13 Late changes secondary to vascular occlusion and remodeling include telangiectasis, microaneurysms, and ischemia-induced neovascularization, with sequelae such as recurrent vitreous hemorrhage, traction retinal detachment, rubeosis iridis, and neovascular glaucoma that can lead to functional loss of the eye.6, 14?20 Inflammatory branch retinal vein occlusions are strongly associated with Beh?et's disease and might contribute to visual loss.21?23
Characteristic features seen with fluorescein angiography in active vasculitis include leakage of dye due to breakdown of the inner blood-retinal barrier, and staining of the blood vessel wall with fluorescein. Such leakage may be focal as seen in sarcoidosis or multiple sclerosis [Figure 2] or more diffuse, as seen in Beh?et's disease and retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease) [Figures 3 and 4]. Diffuse capillary leakage is also a common finding in many conditions such as Beh?et's disease and birdshot chorioretinopathy [Figure 3]. Fluorescein angiography is a more sensitive technique and will frequently show that the vasculitis is more extensive than the clinical examination suggests [Figure 4]. Fluorescein angiography is very useful to delineate areas of capillary nonperfusion, and neovascularization secondary to retinal ischemia [Figure 5]. It is also very valuable to diagnose the presence of inflammatory branch retinal vein occlusion [Figure 6].
The ability to identify retinal vasculitis as ischemic by fluorescein angiography has important implications for management and is discussed later. Other angiographic findings include cystoid macular edema [Figure 7] and optic disc leakage [Figure 8]. Leakage of dye from the optic nerve head arises from dilated capillaries, which may be due to either to primary infiltration as in sarcoidosis24 or secondary vascular changes induced by intraocular inflammation.
In this review, we discuss a practical approach to the diagnosis of retinal vasculitis based on ophthalmoscopic and fluorescein angiographic findings [Table 2].
Retinal vasculitis affecting predominantly the veins (phlebitis) has been described in association with Beh?et's disease, tuberculosis, sarcoidosis, multiple sclerosis, pars planitis, retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease), human immunodeficiency virus infection (HIV) [Figures 1,2,4, 6]. Retinal arteritis is more commonly seen in acute retinal necrosis [Figure 9], idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) [Figure 10] and systemic vasculitides such as SLE, polyarteritis nodosa, and Wegener's granulomatosis, Churg-Strauss syndrome and cryoglobulinemia.1
Cotton-wool spots representing microinfarcts of the retina due to precapillary retinal arteriolar occlusion are most often found in association with systemic vasculitides such as SLE, plyarteritis nodosa, Wegener's granulomatosis, Churg-Strauss syndrome, and cryoglobulinemia [Figure 11].
Retinal vascular lesions are the most common ophthalmic manifestations of SLE and are due to arterial occlusion. Retinopathy generally consists of cotton-wool spots with or without retinal hemorrhages and may occur in the absence of hypertension [Figure 11]. By contrast, a less common but more severe retinal vascular occlusive disease characterized by diffuse arteriolar occlusion with extensive capillary non-perfusion has been described.18 A more focal vascular disease, including retinal artery or vein occlusion may occur. Patients with SLE and raised antiphospholipid antibodies have a higher risk of developing occlusive retinal vascular disease.25 In addition, a patient with severe SLE-associated frosted branch periphlebitis and exudative maculopathy was reported.26 Exacerbations of disease activity might manifest only in the retina as a retinal vascular occlusion7 [Figure 12]. Retinal vascular involvement in polyarteritis nodosa is primarily arterial and gives rise to retinal vasculitis, cotton-wool spots, edema, hemorrhage, and central retinal artery occlusion. The disease may also involve choroidal vessels.9, 12, 27, 28 Curi et al.29 reported aggressive retinal vasculitis involving both arteries and veins in a patient with polyarteritis nodosa.
Susac syndrome is a rare disease of unknown pathogenesis. It is also caused by microangiopathy affecting the arterioles of the brain, retina, and cochlea, giving the classic triad of encephalopathy, branch retinal arterial occlusions, and sensorineural hearing loss. The underlying process is believed to be a small vessel vasculitis causing microinfarcts of the retina, brain, and cochlea. Susac syndrome usually occurs in young women but can affect men. In those cases in which a brain biopsy was performed, histopathologic examination results showed microinfarcts, perivascular inflammatory infiltrates of small vessels consistent with an active small vessel angiitis. Magnetic resonance imaging of the brain often shows lesions suggestive of multiple sclerosis. Fluorescein angiography shows focal nonperfusion of retinal arterioles and arteriolar wall hyperfluorescence.30?33
Intraretinal infiltrates are characteristic of infectious processes, but in the absence of these, they are pathognomonic of Beh?et's disease [Figure 3,7 and 8]. These transient white patches of retinitis, often with small adjacent hemorrhages, are almost always seen in patients with active posterior Beh?et's uveitis. Typically, they are silent on fundus fluorescein angiography.
Retinal vasculitis may be associated with necrotizing retinitis due to ocular toxoplasmosis, acute retinal necrosis, cytomegalovirus (CMV) retinitis, and rarely human T cell lymphoma virus type 1 (HTLV-1) associated uveitis. The hallmark of ocular toxoplasmosis is focal necrotizing retinitis, ultimately resulting in characteristic atrophic scars. Reactivation is frequently situated adjacent to an old atrophic scar with hyper pigmentation along the borders, indicating an old infection (satellite formation). Anterior uveitis, which may be granulomatous, and a secondary rise in intraocular pressure may also be noted. There may be an associated retinal vasculitis, which may be either near to or distant from the focus of active retinochoroiditis [Figure 13]. The arteries are often affected. Kyrieleis arterialitas refers to accumulation of periarterial exudates, which can occur either in the vicinity of the acute retinitis or elsewhere in the retina.34 In rare cases, the vasculitis may be occlusive, resulting in retinal infarction and consequent visual field defects. A case of frosted branch angiitis secondary to toxoplasmic retinochoroiditis was reported.35 In addition, Diaz-Valle et al.,36 reported a case of acute frosted branch angiitis without necrotizing chorioretinitis associated with acquired toxoplasmosis. The patient developed late peripheral retinochoroidal scar. Holland et al.37 reported the development of intraocular inflammatory reactions including vitritis, iridocyclitis, and retinal vasculitis without necrotizing retinal lesions in individuals with acquired systemic toxoplasmosis. Foci of retinitis or inactive retinochoroidal scars were seen in the same eyes during follow-up examinations suggesting that the initial inflammation may be caused by the presence of parasite in retinal tissue. These data strongly suggest that acquired systemic toxoplasmosis infection should be considered in the differential diagnosis of patients with retinal vasculitis, especially in the presence of constitutional symptoms suggesting systemic toxoplasmosis. More severe or atypical ocular presentations occur in immunocompromised patients.
Acute retinal necrosis is caused by viruses of the herpes group, mainly varicella zoster, herpes simplex types 1 and 2, and rarely, cytomegalovirus.38 The prominent features of acute retinal necrosis include peripheral necrotizing retinitis, retinal arteritis, and a prominent inflammatory reaction in the vitreous and anterior chamber [Figure 9]. Optic neuritis occurs in many affected eyes, and complicated rhegmatogenous retinal detachments are often encountered as a late sequela of the condition.39 The disease can progress rapidly with vision loss due to macular involvement, retinal detachment, or optic neuropathy. Vasculitis is predominantly affecting peripheral arteries with closure probably at the origin of the peripheral necrosis and is suspected to be due to antigen-antibody complexes [Figure 9].
In majority of the cases, cytomegalovirus (CMV) retinitis is a manifestation of acquired immunodeficiency syndrome (AIDS), with CMV retinitis being the most common ocular infection in these patients. The classic description of CMV retinitis is one of scattered yellow-white areas of necrotizing retinitis with variable degrees of hemorrhage and mild vitreous inflammation (?cottage cheese with catsup? or ?pizza pie? retinopathy). The pathway of expanding lesions can be predicted by the appearance of venous sheathing or white dots distal to the leading edge. CMV retinitis is often accompanied by varying amounts of retinal vasculitis consisting primarily of perivenous sheathing.40, 41 Frosted branch angiitis was described in patients with AIDS associated with small patches of CMV retinitis.42, 43 Perivasculitis of the peripheral vessels involving veins more often than arteries was described in patients with AIDS. CMV retinitis was not seen in these patients. The vasculitis was thought to be a noninfectious retinopathy associated with AIDS.44, 45 Fine etal.,46 reported a case of HIV-infected child with frosted branch angiitis without CMV retinitis that was refractory to specific anti-cytomegalovirus therapy. The angiitis only improved after subsequent treatment with systemic corticosteroids suggesting that the frosted branch angiitis in this patient was not attributed to CMV.
HTLV-1 infection is endemic in Japan, the Caribbean islands, and parts of Central Africa and South America. The major target cell of HTLV-1 is the CD4+t-cell. HTLV-1 infection is the established cause of adultt-cell leukemia/lymphoma (ATL), an aggressive malignancy of CD4+ lymphocytes; HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis (TSP), a demyelinating inflammatory disease of the spinal cord; and HTLV-1 uveitis (HU), defined as uveitis of undetermined etiology in an HTLV-1 carrier. Clinically, HU has been described as an acute granulomatous or nongranulomatous uveal reactions that were accompanied by vitritris and retinal vasculitis. The ocular disease was considered benign, resolving over weeks in response to corticosteroid treatment, with low incidence of complications and good visual prognosis. Gray-white, granular deposits scattered on the retinal vessels in the posterior pole were noted. Similar materials were also found to deposit on the vitreoretinal interface of the foveolar areas. In addition, retinal vasculitis with sheathing of retinal veins in the periphery was described in patients with HTLV-1-associated myelopathy.47?49 Nakao and Ohba50 reported three HTLV-1-positive Japanese teenagers presenting with extensive retinal periphlebitis resembling frosted branch angiitis. The retinal vascular disease responded poorly to systemic corticosteroids, had a smoldering course, and eventually resulted in diffuse chorioretinal degeneration. Levy-Clarke et al.,51 reported a patient with ATL presenting as a bilateral retinal vasculitis associated with necrotizing retinitis.
IRVAN is a rare clinical entity characterized by bilateral retinal arteritis, numerous aneurysmal dilatations of the retinal and optic nerve head arterioles, peripheral retinal vascular occlusion, neuroretinitis, and uveitis [Figure 10]. This syndrome typically affects young healthy individuals, has a female predominance, and is not associated with any systemic abnormalities. Visual loss is due to exudative maculopathy, and neovascular sequelae of retinal ischemia.52?54 Recently, we reported a patient who presented with features typical of IRVAN in whom medical evaluation disclosed allergic fungal sinusitis.55 Several reports described resolution of aneurysmal dilatations of the retinal arterioles in patients with IRVAN treated with systemic steroids and peripheral retinal photocoagulation [Figure 10].55?58 Recently, Samuel et al.54 recommended early panretinal laser photocoagulation when angiographic evidence of widespread retinal nonperfusion is present, and before (or shortly after) the development of neovascularization. Arterial macroaneurysms, occurring in elderly female patients with sarcoidosis associated with peripheral multifocal chorioretinitis have been described. These patients had severe cardiovascular disease.59?61
Frosted branch angiitis (first described in 1976 by Ito et al.),62 occurs in young, healthy individuals who typically have acute bilateral (but sometimes unilateral) visual loss, associated with anterior and posterior segment inflammation. The retinal findings include swelling of the retina and severe sheathing of the retinal venules, creating the appearance of frosted tree branches. Additional findings include intraretinal hemorrhages, hard exudates, and serous exudative detachments of the macula and periphery [Figure 14]. Fluorescein angiography demonstrates leakage of dye from the vessels, but no evidence of decreased blood flow or occlusion. The disease usually responds rapidly to systemic corticosteroids with rapid resolution of the vascular sheathing. The visual prognosis is usually good and there is no recurrence in most patients. The term "acute frosted retinal periphlebitis" was suggested to describe the condition by Kleiner et al.63 Kleiner64 classified the patients with the appearance of frosted branch angiitis into three subgroups-First are patients with lymphoma or leukemia64 whose disease is due to infiltration with malignant cells (frosted branch-like appearance) [Figure 15] Second is the group of patients who have associated viral infections or autoimmune disease. Frosted branch angiitis was reported in patients with systemic lupus erythematosus,26 Crohn's disease,65 toxoplasmic retinochoroiditis,35, 36 human T cell lymphoma virus type 1 infection,50 AIDS associated with small patches of retinitis,42, 43 HIV without CMV retinitis,46 herpes simplex virus infection,66 and Epstein-Barr virus infection.67 In these patients, frosted branch angiitis is a clinical sign, possibly of immune complex deposition (secondary frosted branch angiitis). Finally, there is the group of otherwise healthy young patients described initially (acute idiopathic angiitis). It is likely that the frosted branch angiitis that developed in these patients represents an immune reaction to a number of different stimuli.68 A case of frosted branch angiitis complicated by bilateral retinal and optic nerve head neovascularization secondary to severe peripheral retinal ischemia was reported. 69 In addition, we reported the unusual association between severe retinal periphlebitis resembling frosted branch angiitis and nonperfused central retinal vein occlusion.20
Patients with ischemic retinal vasculitis represent a major management problem. It is important to identify the presence of retinal ischemia in patients with retinal vasculitis because panretinal laser photocoagulation should be considered when angiographic evidence of widespread retinal nonperfusion is present, and before (or shortly after) the development of neovascularization.
Ischemic retinal vasculitis is frequently seen secondary to tuberculosis and retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease) which is typically an obliterative periphlebitis affecting the retina in multiple quadrants, starting at or anterior to the equator and progressing posteriorly. Occasionally, it can begin close to the optic nerve head, mimicking a vein occlusion. Ophthalmoscopic findings vary and depend on the stage of the disease. Initially, it presents as active retinal periphlebitis with thick exudates around the retinal veins associated with retinal hemorrhages, and hemorrhagic infarctions of the retina [Figure 1,4,16?18]. Healed periphlebitis results in sclerosed white venules, and abnormal vascular anastomosis [Figure 19]. The periphlebitis may cause nonperfusion of a substantial portion of the retina that may lead to proliferative vascular retinopathy with sequelae such as recurrent vitreous hemorrhage, traction retinal detachment, rubeosis iridis, and neovascular glaucoma1, 49, 70?73 [Figures 5, 17?22]. The management of tuberculous retinal vasculitis or retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease) requires the use of systemic steroids and appropriate antituberculous therapy. New vessel formation associated with retinal vasculitis and capillary closure responds to panretinal photocoagulation [Figure 21]. Early vitrectomy and adequate endolaser photocoagulation should be considered in eyes with non-resolving vitreous hemorrhage associated with active fibrovascular proliferation14 [Figure 22].
Ischemic retinal vasculitis may also be secondary to Beh?et's disease and multiple sclerosis. The diagnosis is made using criteria proposed by the International Study Group for Beh?et's disease in 1990.74 The criteria require recurrent oral ulceration as an essential symptom plus any two or more symptoms of genital ulceration, eye lesions, skin lesions and a positive pathergy test to make a diagnosis of Beh?et's disease. Inflammatory eye disease generally appears later than the oral ulceration and develops in about 70% of patients in Japan. The ocular manifestations of Beh?et's disease typically include recurrent attacks of anterior uveitis, with or without hypopyon, cellular infiltration and opacification of the vitreous, retinal vasculitis [Figures 6 and 23], retinal infiltrates [Figures 3, 7 and 8] and hemorrhages, cystoid macular edema [Figure 8] and disc hyperemia. Retinal vasculitis and recurrent vasoocclusive episodes are the major causes of visual morbidity. In addition, inflammatory retinal vein occlusions are strongly associated with Beh?et's disease21?23, 75] [Figures 6 and 23]. Fluorescein angiography may show diffuse retinal vascular leakage, late staining of the vasculature, leakage from the disc, macular edema, areas of capillary dropout, and neovascularization [Figures 3, 6?8 and 23].
Various ocular inflammatory changes have been described in patients with multiple sclerosis and may be the presenting sign of the disease. They include nongranulomatous and granulomatous iridocyclitis, intermediate uveitis, retinitis, periphlebitis [Figure 2] and optic neuritis.15?17, 76?83 Retinal periphlebitis has been described as a common manifestation of multiple sclerosis. It has been observed with an average frequency of 11.5% in more than 3000 published cases of MS examined for sheathing.79 In an autopsy series of 93 eyes from patients with definite multiple sclerosis, segmental lympho-plasmacytic perivenous infiltrates were found in seven eyes and focal lymphocytic or granulomatous retinitis was present in five eyes.76 The foci of granulomatous retinal inflammatory cells were noted in the inner retina and overlying vitreous and corresponded to white plaques visible on the inner retinal surface on gross examination.76 Round dot-like opacities, the diameter of a medium-sized vein, visible in the vitreous immediately overlying the retina were originally described by Rucker.81 These have come to be known as ?Rucker bodies.? It has been demonstrated that demyelinative plaques in the brain typically encircle a venule and that in an active lesion perivenular infiltrates are present.82 These changes appear similar to the periphlebitis occurring in the retina. The periphlebitis can progress to occlusive peripheral vasculitis, which results in peripheral retinal neovascularization and tractional or rhegmatogenous retinal detachments or both. Peripheral scatter photocoagulation and vitrectomy may be required to stabilize the proliferative retinopathy.15?17, 83
Retinal periphlebitis associated with sarcoidosis is usually nonocclusive, sometimes subclinical and only visible on fluorescein angiography, associated with typical segmental cuffing or more extensive sheathing and perivenous exudates, which are usually indicated as ?candle wax drippings? [Figure 24]. Multiple small round chorioretinal lesions are frequently seen in peripheral fundus. Peripheral multifocal chorioretinitis and choroidal granuloma were described. Optic disc swelling may be caused by uveitis, raised intracranial pressure, or optic nerve infiltration. Arterial macroaneurysms, occurring in elderly female patients with peripheral multifocal chorioretinitis have been described, and were associated with severe cardiovascular disease.84, 85 Development of capillary nonperfusion, and subsequent neovascularization as well as branch and central retinal vein occlusions have been described.86?89
Idiopathic recurrent branch retinal arterial occlusion is a clinical syndrome characterized by recurrent multiple branch retinal arterial occlusions of unknown cause in one or both eyes of healthy middle-aged patients. Ophthalmoscopic and fluorescein angiographic findings suggested focal arteritis and arteriolitis as the cause of the obstructions. Eyes that have large areas of retinal ischemia may subsequently develop preretinal neovascularization. The prognosis for maintaining good visual acuity is good. Detailed investigation of these patients has failed to reveal a systemic etiology. Vestibuloauditory and/or transient sensorimotor symptoms were detected in 50% of patients. It is postulated that many of the patients have mild or partial manifestations of the microangiopathic syndrome of encephalopathy, hearing loss, and retinal arteriolar occlusions.11 Occlusive retinal vasculitis, and subsequent retinal neovascularization6 and neovascular glaucoma19 were also reported in patients with Crohn's disease. Occlusive retinal vasculitis has also been reported in patients infected with Rift Valley fever virus90, 91 [Figure 25] and West Nile virus.92?94
The search for a cause in patients with retinal vasculitis often involves a multidisciplinary approach and laboratory investigation2, 95 [Table 3]. Discrimination between infectious or noninfectious etiology of retinal vasculitis is important because treatment is different. Immunosuppressive therapy may be essential in certain disorders but it might be deleterious in infectious entities. Once an infectious cause is believed to be unlikely, an associated systemic disease should be considered and an appropriate investigation instituted. In cases of diagnostic doubt, malignancy must be ruled out and should certainly be considered if, after an initial improvement with therapy, the patient's disease rapidly becomes refractory to treatment. The ophthalmologist, therefore, has a major role in clarifying the nosologic and diagnostic debate in patients with retinal vasculitis.
The laboratory work-up of a patient with retinal vasculitis should be based on a differential diagnosis derived from a detailed history, review of systems, and physical examination. If the patient's medical history, review of systems, or ocular examination suggests an underlying systemic disease, then the diagnostic work-up should be tailored for that disease. The absence of any diagnostic clues from history makes idiopathic retinal vasculitis most likely. If, however, the patient has no signs or symptoms suggestive of an associated disease then the work-up of the patient is limited to a fluorescein angiogram, complete blood count, erythrocyte sedimentation rate, VDRL, FTA-ABS, blood chemistry, urinalysis, tuberculin skin testing, HIV serology, and chest radiograph. Numerous studies have shown that little additional information is gained by ?blind? investigation of the patient and that pursuing this is neither time nor cost effective.
Source of Support: Nil
Conflict of Interest: None declared.
|1.||Abu El-Asrar AM,Herbort CP,Tabbara KF. Retinal vasculitisOcul Immunol InflammYear: 2005134153316321886|
|2.||Perez VL,Chavala SH,Ahmed M,Chu D,Zafirakis P,Baltatzis S,et al. Ocular manifestations and concepts of systemic vasculitidesSurv OphthalmolYear: 20044939941815231396|
|3.||Graham EM,Spalton DJ,Barnard RO,Garner A,Russell RW. Cerebral and retinal vascular changes in systemic lupus erythematosusOphthalmologyYear: 19859244483991132|
|4.||Au A,O'Day J. Review of severe vaso-occlusive retinopathy in systemic lupus erythematosus and the antiphosopholipid syndrome: Associations, visual outcomes, complications and treatmentClin Exp OphthalmolYear: 20043287100|
|5.||Palmer HE,Stanford MR,Sanders MD,Graham EM. Visual outcome of patiets with idiopathic ischaemic and non-ischaemic retinal vasculitisEyeYear: 19961034388796160|
|6.||Saatci OA,Ko?ak N,Durak I,Ergin MH. Unilateral retinal vasculitis, branch retinal artery occlusion and subsequent retinal neovascularization in Crohn's diseaseInt OphthalmolYear: 200124899212201349|
|7.||el-Asrar AM,Naddaf HO,Al-Momen A,Al-Balla SR. Systemic lupus erythematosus flare-up manifesting as a cilioretinal artery occlusionLupusYear: 19954158607795623|
|8.||Iida T,Spaide RF,Kantor J. Retinal and choroidal arterial occlusion in Wegener's granulomatosisAm J OphthalmolYear: 2002133151211755858|
|9.||Hsu CT,Kerrison JB,Miller NR,Goldberg MF. Choroidal infarction, ischemic optic neuropathy, and central retinal artery occlusion from polyarteritis nodosaRetinaYear: 2001213485111508881|
|10.||Skrapari I,Kagkelari E,Charitatos E,Pantelidaki C,Gounaris T,Sioula E. Acute painless monocular visual loss due to central retinal artery occlusion in a patient with Churg-Strauss vasculitisClin RheumatolYear: 20082712512717674118|
|11.||Johnson MW,Thomley ML,Huang SS,Gass JD. Idiopathic recurrent branch retinal arterial occlusion: Natural history and laboratory evaluationOphthalmologyYear: 199410148098127568|
|12.||Emad Y,Basaffar S,Ragab Y,Zeinhom F,Gheita T. A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitisClin RheumatolYear: 200726814616575492|
|13.||Bentley CR,Stanford MR,Shilling JS,Sanders MD,Graham EM. Macular ischaemia in posterior uveitisEyeYear: 1993741148224296|
|14.||el-Asrar AM,AL-Kharashi SA. Full panretinal photocoagulation and early vitrectomy improve prognosis of retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease)Br J OphthalmolYear: 20028612485112386081|
|15.||Vine AK. Severe periphlebitis, peripheral retinal ischemia, and preretinal neovascularization in patients with multiple sclerosisAm J OphthalmolYear: 199211328321728142|
|16.||Morse PH. Retinal venous sheathing and neovascularization in disseminated sclerosisAnn OphthalmolYear: 19757949521147522|
|17.||Valentincic NV,Kraut A,Rothova A. Vitreous hemorrhage in multiple sclerosis-associated uveitisOcul Immuno InflammYear: 2007151925|
|18.||Jabs DA,Fine SL,Hochberg MC,Newman SA,Heiner GG,Stevens MB. Severe retinal vaso-occlusive disease in systemic lupus erythematosusArch OphthalmolYear: 1986104558633954661|
|19.||Salmon JF,Ursell PG,Frith P. Neovascular glaucoma as a complication of retinal vasculitis in Crohn's diseaseAm J OphthalmolYear: 20001305283011024432|
|20.||Abu El-Asrar AM,Al-Obeidan SA,Abdel Gader AGM. Retinal periphlebitis resembling frosted branch angiitis with nonperfused central retinal vein occlusionEur J OphthalmolYear: 2003138071214700106|
|21.||Sakane T,Takeno M. Novel approaches to Beh?et's diseaseExp Opin Invest DrugsYear: 2000919932005|
|22.||Okada AA. Drug therapy in Beh?et's diseaseOcul Immunol InflammYear: 20008859110980680|
|23.||Graham EM,Stanford MR,Sander MD,Kasp E,Dumonde DC. A point prevalence study of 150 patients with idiopathic retinal vasculitis: I: Diagnostic value of ophthalmological featuresBr J OphthalmolYear: 198973714212804027|
|24.||Gass JD,Olson CL. Sarcoidosis with optic nerve and retinal involvementArch OphthalmolYear: 19769494550938285|
|25.||Asherson RA,Merry P,Acheson JF,Harris EN,Hughes GR. Antiphospholipid antibodies: A risk factor for occlusive ocular vascular disease in systemic lupus erythematosus and the primary antiphospholipid syndromeAnn Rheum DisYear: 198948358612637678|
|26.||Quillen DA,Stathopoulos NA,Blankenship GW,Ferriss JA. Lupus associated frosted branch periphlebitis and exudative maculopathyRetinaYear: 199717449519355196|
|27.||Morgan CM,Foster CS,D'Amico DJ,Gragoudas ES. Retinal vasculitis in polyarteritis nodosaRetinaYear: 1986620592883710|
|28.||Akova YA,Jabbur NS,Foster CS. Ocular presentation of polyarteritis nodosa: Clinical course and management with steroid and cytotoxic therapyOphthalmologyYear: 19931001775817903120|
|29.||Curi AL,Freeman G,Pavesio C. Aggressive retinal vasculitis in polyarteritis nodosaEyeYear: 2001152293111339598|
|30.||O'Halloran HS,Pearson PA,Lee WB,Susac JO,Berger JR. Microangiopathy of the brain, retina, and cochlea (Susac syndrome): A report of five cases and a review of the literatureOphthalmologyYear: 19981051038449627654|
|31.||Do TH,Fisch C,Evoy F. Susac syndrome: Report of four cases and review of the literatureAJNR Am J NeuroradiolYear: 200425382815037459|
|32.||Susac JO,Egan RA,Rennebohm RM,Lubow M. Susac's syndrome: 1975-2005 microangiopathy/autoimmune endotheliopathyJ Neurol SciYear: 2007257270217331544|
|33.||Martinet N,Fardeau C,Adam R. Fluorescein and indocyanine green angiographies in susac syndromeRetinaYear: 200727128342|
|34.||Theodossiodis P,Kokolakis S,Ladas I,Kollia AC,Chatzoulis D,Theodossiadis G. Retinal vascular involvement in acute toxoplasmic retinochoroiditisInt OphthalmolYear: 19951919248537191|
|35.||Ysasaga JE,Davis J. Frosted branch angiitis with ocular toxoplasmosisArch OphthalmolYear: 19991171260110496406|
|36.||Diaz-Valle D,Diaz-Rodriguez E,Diaz-Valle T,Ben?tez del Castillo JM,Toledano N,Fern?ndez Ace?ero MJ. Frosted branch angiitis and late peripheral retinochoroidal scar in a patient with acquired toxoplasmosisEur J OphthalmolYear: 200313726814620180|
|37.||Holland GN,Muccioli C,Silveira C,Weisz JM,Belfort R Jr,O'Connor GR. Intraocular inflammatory reactions without focal necrotizing retinochoroiditis in patients with acquired systemic toxoplasmosisAm J OphthalmolYear: 19991284132010577581|
|38.||Ganatra JB,Chandler D,Santos C,Kuppermann B,Margolis TP. Viral causes of the acute retinal necrosis syndromeAm J OphthalmolYear: 20001291667210682968|
|39.||Holland GN; Executive Committee of the American Uveitis Society. Standard diagnostic criteria for the acute retinal necrosis syndromeAm J OphthalmolYear: 199411766378172275|
|40.||Yoser SL,Forster DJ,Rao NA. Systemic viral infections and their retinal and choroidal manifestationsSurv OphthalmolYear: 199337313528387231|
|41.||Culbertson WW. Infections of the retina in AIDSInt Ophthalmol ClinYear: 198929108182541096|
|42.||Spaide RF,Vitale AT,Toth IR,Oliver JM. Frosted branch angiitis associated with cytomegalovirus retinitisAm J OphthalmolYear: 199211352281349456|
|43.||Geier SA,Nasemann J,Klauss V,Kronawitter U,Goebel FD. Frosted branch angiitis in a patient withthe acquired immunodeficiency syndromeAm J OphthalmolYear: 199211320351550190|
|44.||Kestelyn P,Lepage P,Van de Perre P. Perivasculitis of the retinal vessels as an important sign in children with AIDS-related complexAm J OphthalmolYear: 198510061454050937|
|45.||Kestelyn P,Van de Perre P,Rouvroy D,Lepage P,Bogaerts J,Nzaramba D,et al. A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome in AfricaAm J OphthalmolYear: 198510023082992280|
|46.||Fine HF,Smith JA,Murante BL,Nussenblatt RB,Robinson MR. Frosted branch angiitis in a child with HIV infectionAm J OphthalmolYear: 2001131394611239884|
|47.||Sasaki K,Morooka I,Inomata H,Kashio N,Akamine T,Osame M. Retinal vasculitis in human t-lymphotropic virus type 1 associated myelopathyBr J OphthalmolYear: 19897381252818990|
|48.||Nakao K,Ohba N. Clinical features of HTLV-1 associated uveitisBr J OphthalmolYear: 19937727498100446|
|49.||Nakao K,Ohba N. HTLV-1 associated uveitis revisited:Characteristic grey-white, granular deposits on retinal vesselsBr J OphthalmolYear: 199680719228949716|
|50.||Nakao K,Ohba N. Human t-cell lymphotropic virus type 1-associated retinal vasculitis in childrenRetinaYear: 20032319720112707599|
|51.||Levy-Clarke GA,Buggage RR,Shen D,Vaughen LO,Chan CC,Davis JL. Human t-cell lymphotropic virus-type 1 associated t-cell leukemia/lymphoma masquerading as necrotizing retinal vasculitisOphthalmologyYear: 200210917172212208722|
|52.||Kincaid J,Schatz H. Bilateral retinal arteritis with multiple aneurysmal dilatationsRetinaYear: 1983317186635351|
|53.||Chang TS,Aylward W,Davis JL,Mieler WF,Oliver GL,Maberley AL,et al. Idiopathic retinal vasculitis, aneurysms, and neuro-retinitisOphthalmologyYear: 19951021089979121757|
|54.||Samuel MA,Equi RA,Chang TS,Mieler W,Jampol LM,Hay D,et al. Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN): New observations and a proposed staging systemOphthalmologyYear: 20071141526917678691|
|55.||Abu El-Asrar AM,Jestaneiah S,Al-Serhani AM. Regression of aneurysmal dilatations in a case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) associated with allergic fungal sinusitisEyeYear: 200418197914762419|
|56.||Owens SL,Gregor ZJ. Vanishing retinal arterial aneurysms: A case reportBr J OphthalmolYear: 19927663781420048|
|57.||Sashihara H,Hayashi H,Oshima K. Regression of retinal arterial aneurysms in a case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN)RetinaYear: 199919250110380034|
|58.||Tomita M,Matsubara T,Yamada H,Takahashi K,Nishimura T,Sho K,et al. Long term follow up in a case of successfully treated idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN)Br J OphthalmolYear: 200488302314736797|
|59.||Rothova A,Lardenoye C. Arterial macroaneurysms in peripheral multifocal chorioretinitis associated with sarcoidosisOphthalmologyYear: 1998105139379709748|
|60.||Verougstraete C,Snyers B,Leys A,Caspers-Velu LE. Multiple arterial ectasias in patients with sarcoidosis and uveitisAm J OphthalmolYear: 20011312233111228299|
|61.||Yamanaka E,Ohguro N,Kubota A,Yamamoto S,Nakagawa Y,Tano Y. Features of retinal arterial macroaneurysms in patients with uveitisBr J OphthalmolYear: 200488884615205230|
|62.||Ito Y,Nakano M,Kyu N,Takeuchi M. Frosted branch angiitis in a childJpn J Clin OphthalmolYear: 197630797803|
|63.||Kleiner RC,Kaplan HJ,Shakin JL,Yannuzzi LA,Crosswell HH Jr,McLean WC Jr. Acute frosted retinal periphlebitisAm J OphthalmolYear: 198810627343394765|
|64.||Kleiner RC. Frosted branch angiitis: Clinical syndrome or clinical sign?RetinaYear: 19971737019355182|
|65.||Sykes SO,Horton JC. Steroid-responsive retinal vasculitis with a frosted branch appearance in Crohn's diseaseRetinaYear: 19971745149355197|
|66.||Markomichelakis NN,Barampouti F,Zafirakis P,Chalkiadakis I,Kouris T,Ekonomopoulos N. Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2RetinaYear: 199919455710546946|
|67.||Farrardo J,Fonollosa A,Segura A,Garcia-Arumi J. Frosted branch angiitis associated with Epstein-Barr virus sytemic infectionOcul Immunol InflammYear: 20081641318379942|
|68.||Sugin SL,Henderly DE,Friedman SM,Jampol LM,Doyle JW. Unilateral frosted branch angiitisAm J OphthalmolYear: 199111168252039035|
|69.||Borkowski LM,Jampol LM. Frosted branch angiitis complicated by retinal neovascularizationRetinaYear: 199919454510546945|
|70.||Helm CJ,Holland GN. Ocular tuberculosisSurv OphthalmolYear: 199338229568310395|
|71.||Rosen PH,Spalton DJ,Graham EM. Intraocular tuberculosisEyeYear: 19904486922209914|
|72.||Gupta A,Gupta V,Arora S,Dogra MR,Bambery P. PCR-positive tubercular retinal vasculitis: Clinical characteristics and managementRetinaYear: 2001214354411642371|
|73.||Biswas J,Sharma T,Gopal L,Madhavan HN,Sulochana KN,Ramakrishnan S. Eales' disease: An updateSurv OphthalmolYear: 20024719721412052408|
|74.||International Study Group for Beh?et's Disease. Criteria for diagnosis of Beh?et's diseaseLancetYear: 19903351078801970380|
|75.||Verity DH,Wallace GR,Vaughan RW,Stanford MR. Beh?et's disease: From Hippocrates to the third millenniumBr J OphthalmolYear: 20038711758312928293|
|76.||Arnold AC,Usaf M,Pepose JS,Foos RY. Retinal periphlebitis and retinitis in multiple sclerosis: I: Pathologic characteristicsOphthalmologyYear: 198491255626717913|
|77.||Lim JI,Tessler HH,Goodwin JA. Anterior granulomatous uveitis in patients with multiple sclerosisOphthalmologyYear: 19919814252008270|
|78.||Graham EM,Francis DA,Sanders MD,Rudge P. Ocular inflammatory changes in established multiple sclerosisJ Neurol Neurosurg PsychiatryYear: 198952136032614430|
|79.||Engell T,Andersen PK. The frequency of periphlebitis retinae in multiple sclerosisActa Neurol ScandYear: 19826560187113665|
|80.||Birch MK,Barbosa S,Blumhardt LD,O'Brien C,Harding SP. Retinal venous sheathing and the blood-retinal barrier in multiple sclerosisArch OphthalmolYear: 19961143498540848|
|81.||Rucker CW. Sheathing of the retinal veins in multiple sclerosis: Review of pertinent literatureMayo Clin ProcYear: 197247335404555346|
|82.||Prineas JW,Wright RG. Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosisLab InvestYear: 19783840921205724|
|83.||Towler HM,Lightman S. Symptomatic intraocular inflammation in multiple sclerosisClin Exp OphthalmolYear: 20002897102|
|84.||Rothova A. Ocular involvement in sarcoidosisBr J OphthalmolYear: 200084110610611110|
|85.||Nicholas J. SarcoidosisCurr Opin OphthalmolYear: 200213393612441843|
|86.||DeRosa AJ,Margo CE,Orlick ME. Hemorrhagic retinopathy as the presenting manifestation of sarcoidosisRetinaYear: 19951542278594636|
|87.||Ohara K,Okubo A,Saski H. Branch retinal vein occlusion in a child with ocular sarcoidosisAm J OphthalmolYear: 199511980677785703|
|88.||Kimmel AS,McCarthy MJ,Blodi CF,Folk JC. Branch retinal vein occlusion in sarcoidosisAm J OphthalmolYear: 198910756122712145|
|89.||Duker JS,Brown GC,McNamara JA. Proliferative sarcoid retinopathyOphthalmologyYear: 198895168062466228|
|90.||Siam AL,Meegan JM,Gharbawi KF. Rift Valley fever ocular manifestations: Observations during the 1977 epidemic in EgyptBr J OphthalmolYear: 198064366747192158|
|91.||Al-Hazmi A,Al-Rajhi AA,Abboud EB,Ayoola EA,Al-Hazmi M,Saadi R,et al. Ocular complications of Rift Valley fever outbreak in Saudi ArabiaOphthalmologyYear: 2005112313815691569|
|92.||Kaiser PK,Lee MS,Martin DA. Occlusive vasculitis in a patient with concomitant West Nile virus infectionAm J OphthalmolYear: 20031369283014597052|
|93.||Chan CK,Limstrom SA,Tarasewicz DG,Lin SG. Ocular features of West Nile virus infection in North America: A study of 14 eyesOphthalmologyYear: 200611315394616860390|
|94.||Teitelbaum BA,Newman TL,Tresley DJ. Occlusive retinal vasculitis in a patient with West Nile virusClin Exp OptomYear: 200790463717958570|
|95.||Herbort CP,Cimino L,Abu El-Asrar AM. Ocular vasculitis: A multidisciplinary approachCurr Opin RheumatolYear: 200517253315604901|
Disorders associated with retinal vasculitis1
|Tuberculosis, syphilis, lyme disease, Whipple's disease, brucellosis, cat scratch disease, endophthalmitis, post-streptococcal syndrome|
|Human T cell lymphoma virus type 1, cytomegalovirus, herpes simplex virus, varicella zoster virus, Epstein-Barr virus, Rift Valley fever virus, hepatitis, acquired immunodeficiency syndrome, West Nile virus infection, Dengue fever virus|
|Mediterranean spotted fever, Rocky Mountain spotted fever|
|Microangiopathy of the brain, retina, and cochlea (Susac syndrome)|
|Systemic inflammatory diseases|
|Systemic lupus erythematosus|
|Sl?gren's A antigen|
|Frosted branch angiitis|
|Idiopathic retinal vasculitis, aneurysms, and neuroretinitis|
|Acute multifocal hemorrhagic retinal vasculitis|
|Idiopathic recurrent branch retinal arterial occlusion|
Differential diagnosis of retinal vasculitis based on ophthalmoscopic findings
|Ophthalmoscopic finding||Possible diagnoses|
|Phlebitis||Beh?et's disease, tuberculosis, sarcoidosis, multiple sclerosis, pars planitis, Eales' disease, human immunodeficiency virus infection|
|Arteritis||Acute retinal necrosis, idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN), systemic vasculitides such as systemic lupus erythematosus (SLE), polyarteritis nodosa (PAN), Wegener's ganulomatosis, Churg-Strauss syndrome, and cryoglobulinemia|
|Cotton-wool spots||Systemic vasculitides such as SLE, PAN, Wegener's granulomatosis, Churg-Strauss syndrome, and cryoglobulinemia|
|Intraretinal infiltrates||Beh?et?s disease, rickettsial infection, cat scratch disease|
|Necrotizing retinitis||Ocular toxoplasmosis, acute retinal necrosis, cytomegalovirus retinitis|
|Aneurysmal dilatations of the retinal and optic nerve head arterioles||IRVAN, sarcoidosis|
|Frosted branch angiitis||Idiopathic, infiltration with malignant cells (lymphoma or leukemia), SLE, Crohn's disease, toxoplasmic retinochoroiditis, human T cell lymphoma virus type 1 infection, acquired immunodeficiency syndrome, human immunodeficiency virus infection, herpes simplex virus infection, Epstein-Barr virus infection|
|Retinal ischemia||Tuberculosis, Eales' disease, Beh?et?s disease, multiple sclerosis (rare), sarcoidosis (rare)|
|Inflammatory branch retinal vein occlusion||Beh?et's disease, tuberculosis, sarcoidosis (rare)|
|Retinal arterial occlusions||SLE, PAN, Wegener's granulomatosis, Churg-Strauss syndrome, Crohn's disease, Susac syndrome, cat scratch disease, Mediterranean spotted fever, ocular toxoplasmosis|
Diagnostic studies performed on patients with retinal vasculitis*
|Complete blood count with differential|
|Erythrocyte sedimentation rate|
|Serum chemistry panel with tests for renal and liver functions|
|Venereal Disease Research Laboratory (VDRL) test, Fluorescent treponemal antibody absorption (FTA-ABS) test|
|Tuberculin skin testing|
|Gamma interferon release assays for tuberculosis|
|Lyme disease serology|
|Dengue virus serology|
|Cat scratch disease serology|
|Human immunodeficiency virus, human T cell lymphoma virus type1, cytomegalovirus, herpes simplex virus, varicella zoster virus, hepatitis virus, and West Nile virus serology|
|Polymerase chain reaction to identify pathogens in ocular specimens|
|Serum angiotensin-converting enzyme|
|Antineutrophil cytoplasmic antibody|
|Antiphospholipid antibodies (lupus anticoagulants and anticardiolipin antibodies)|
|Serum complement, CH50, AH50|
|Extractable nuclear antigen|
|Serum protein electrophoresis|
|Human leukocyte antigen testing|
|Cerebrospinal fluid cytology and cell count|
|Optical coherence tomography|
|Magnetic resonance imaging|
The diagnostic work-up should be tailored according to the patient?s medical history, review of systems, and physical examination.1
Keywords: Fluorescein Angiography, Retina, Vasculitis.
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