Document Detail


Differential diagnosis in patients with ring-like thallium-201 uptake in brain SPECT.
MedLine Citation:
PMID:  12416581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to investigate lesions with ring-like thallium-201 (201Tl) uptake and to determine whether SPECT provides any information in differential diagnosis. METHODS: A total of 244 201Tl SPECT images were reviewed. In each study, early (15 min postinjection) and late (3 hr) brain SPECT images were obtained with 111 MBq of 201Tl. The early uptake ratio (ER; lesion to normal brain average count ratio) and the late uptake ratio (LR) and the L/E ratio (ratio of LR to ER) were calculated. RESULTS: Ring-like uptake was observed in pre-therapeutic 26 SPECT images, including ten glioblastoma multiformes (ER, 3.45 +/- 0.64; LR, 2.74 +/- 0.54; L/E ratio 0.80 +/- 0.13), five meningiomas (6.48 +/- 2.34; 4.41 +/- 1.41; 0.72 +/- 0.19), four metastatic lung cancers (3.47 +/- 1.23; 2.40 +/- 0.98; 0.70 +/- 0.14), four brain abscesses (2.48 +/- 1.06; 1.59 +/- 0.30; 0.78 +/- 0.15), one invasive lesion of squamous cell carcinoma from the ethmoid sinus (1.54; 1.52; 0.99), one medulloblastoma (3.53; 3.52; 1.00) and one hematoma (3.32; 2.36; 0.71). The ER of meningioma was significantly higher than those of glioblastoma multiforme (p < 0.0005), metastatic lung cancer (p < 0.005) and brain abscess (p < 0.0005). There were no significant differences among these three entities. The LR of meningioma was significantly higher than those of glioblastoma multiforme (p < 0.005), metastatic lung cancer (p < 0.005) and brain abscess (p < 0.0001). The LR of brain abscess was significantly lower than that of glioblastoma multiforme (p < 0.05). The L/E ratio could not differentiate these four entities. CONCLUSION: High ER and high LR in a lesion with ring-like uptake is likely an indicator of meningioma. The LR of brain abscess was significantly lower than that of glioblastoma multiforme, but 201T1 SPECT has still difficulty in differentiating abscess from brain tumor.
Authors:
Keiko Kinuya; Masahiro Ohashi; Syotaro Itoh; Kenji Yamamoto; Sotaro Sakai; Kiyoshi Kakuda; Koji Nobata; Naoko Kato; Shintaro Terahara; Suzuka Taki
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  16     ISSN:  0914-7187     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Tonami General Hospital, Toyama, Japan. dinky@d9.dion.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / radionuclide imaging*
Brain Abscess / diagnosis,  radionuclide imaging*
Brain Neoplasms / diagnosis,  radionuclide imaging*,  secondary
Carcinoma, Squamous Cell / diagnosis
Diagnosis, Differential
Ethmoid Sinus / radionuclide imaging
Female
Glioblastoma / diagnosis,  secondary
Hematoma / radionuclide imaging
Humans
Intracranial Hemorrhages / radionuclide imaging
Lung Neoplasms / pathology,  secondary
Male
Medulloblastoma / diagnosis,  secondary
Meningioma / diagnosis,  secondary
Middle Aged
Neoplasm Invasiveness
Neoplasms, Nerve Tissue / diagnosis,  radionuclide imaging*,  secondary
Paranasal Sinus Neoplasms / diagnosis
Radiopharmaceuticals / diagnostic use
Retrospective Studies
Thallium / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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