Document Detail

Differential diagnosis of genitourinary tumors using monoclonal antibodies to intermediate filament proteins.
MedLine Citation:
PMID:  2775372     Owner:  NLM     Status:  MEDLINE    
Definitive diagnosis of poorly differentiated and metastatic neoplasms may be impossible using conventional histologic criteria. Recent developments in cell biology and immunology now enable us to answer such difficult diagnostic problems. Several varieties of structural proteins can be identified in malignant cells using monoclonal antibodies. The composition of these proteins can yield information regarding the origin of a neoplasm. Intermediate filaments are one such family of structural proteins. By characterization of these proteins, using a panel of monoclonal antibodies, poorly differentiated tumors may be definitively classified as carcinomas, sarcomas, lymphomas, or neural tumors. This approach to tumor diagnosis is now applicable to difficult problems in clinical urology.
S A Lofton; A M Gown; A M Vogel; J N Krieger
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Urology     Volume:  33     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-9     Citation Subset:  IM    
Department of Pathology, University of Washington School of Medicine, Seattle.
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MeSH Terms
Adenocarcinoma / diagnosis
Antibodies, Monoclonal / diagnostic use*
Carcinoma, Renal Cell / diagnosis
Carcinoma, Squamous Cell / diagnosis
Carcinoma, Transitional Cell / diagnosis
Intermediate Filament Proteins / immunology*
Kidney Neoplasms / diagnosis
Urogenital Neoplasms / diagnosis*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Intermediate Filament Proteins

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