Document Detail

Differential diagnosis of chronic urticaria.
MedLine Citation:
PMID:  18426134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To review diseases that can present with cutaneous signs and symptoms that mimic those observed in chronic urticaria and to discuss the workup necessary to distinguish these diseases from chronic urticaria. DATA SOURCES: We performed a PubMed search using the following keywords: urticaria, cryopyrin, Sweet syndrome, subacute cutaneous lupus, urticarial vasculitis, urticaria pigmentosa, angioedema, fixed drug eruption, bullous pemphigoid, and reticular erythematous mucinosis. Appropriate chapters in general dermatology textbooks were also reviewed. STUDY SELECTION: Articles that related to disease states, which present with persistent urticarial lesions, were catalogued for use in this review. RESULTS: Besides acute, chronic, and physical urticarias, there are 2 categories of diseases that have urticarial lesions. The first group includes those in which the skin lesions are almost indistinguishable from those seen in patients with chronic idiopathic urticaria. Thus, the diagnosis relies on a careful history and physical examination, and in some cases laboratory studies are required. The second group are ones that have skin lesions that at one point in their development have an urticaria-like appearance or on rare occasion may have such lesions. These latter diseases are numerous, and we have tried to highlight the ones that most mimic chronic idiopathic urticaria or are more common. CONCLUSIONS: A working knowledge of the diseases that can present with urticarial lesions is essential to accurately diagnose and effectively treat these symptomatic and sometimes serious conditions.
Lindsey A Brodell; Lisa A Beck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  100     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-05-20     Revised Date:  2008-08-27    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-8; quiz 188-90, 215     Citation Subset:  IM    
Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents / pharmacology,  therapeutic use
Chronic Disease
Diagnosis, Differential
Skin / immunology
Skin Diseases / diagnosis*,  drug therapy,  immunology,  physiopathology
Urticaria / diagnosis*,  drug therapy,  immunology,  physiopathology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents
Comment In:
Ann Allergy Asthma Immunol. 2008 Mar;100(3):191-2   [PMID:  18426135 ]
Ann Allergy Asthma Immunol. 2008 Jul;101(1):111-2   [PMID:  18683302 ]

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