Document Detail

Differential development of tolerance to the effects of d-amphetamine and fenfluramine on food intake in baboons.
MedLine Citation:
PMID:  2319478     Owner:  NLM     Status:  MEDLINE    
Food intake of six adult male baboons (Papio cynocephalus anubis) was monitored during daily 22-hr experimental sessions. Food was available under a chain schedule with two components. After completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the second "consumption component," during which each response produced a 1-g food pellet. After a 10-min interval in which no response occurred, the consumption component was terminated. Complete dose-response functions for amphetamine and fenfluramine were determined before, during and after a period of repeated administration of each drug. On the first day of repeated administration both drugs decreased intake during both the first 8 hr and the entire session to 65% of baseline. Total intake returned to 93% of baseline during repeated amphetamine, but only to 76% of baseline during repeated fenfluramine. There was no recovery of intake, however, during the first 8 hr of the session. Baboons given repeated amphetamine were tolerant to the food intake decreasing effects of acute amphetamine, but not acute fenfluramine. Baboons given repeated fenfluramine did not develop tolerance to the effects of fenfluramine or amphetamine on food intake. The absence of cross-tolerance or increased sensitivity between amphetamine and fenfluramine suggests that although both serotonergic and dopaminergic systems are involved in feeding, they can influence food intake independently.
R W Foltin
Related Documents :
512568 - Schedule-induced drinking: rate of food delivery and herrnstein's equation.
6436798 - Effects of thyrotropin-releasing hormone (trh) and mk-771 on behavior of squirrel monke...
8333588 - Effects of manipulating food availability on ethanol self-administration by p rats in a...
6875638 - Organization of synaptic inputs to paracerebral feeding command interneurons of pleurob...
11964698 - Food allergy: in-vivo diagnostics including challenge.
17749628 - Archeological survey and excavation in iran, 1961.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  252     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-03     Completed Date:  1990-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  960-9     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Dextroamphetamine / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Drug Tolerance
Eating / drug effects*
Fenfluramine / administration & dosage,  pharmacology*
Injections, Intramuscular
Grant Support
Reg. No./Substance:
458-24-2/Fenfluramine; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Smoked marijuana effects on tobacco cigarette smoking behavior.
Next Document:  Low-dose caffeine discrimination in humans.