Document Detail


Differential development of early hypertension in heterozygous transgenic TGR(mREN2)27 rats.
MedLine Citation:
PMID:  9605382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to determine blood pressures in young heterozygous transgenic rats harbouring the Ren-2 mouse gene, TGR(mREN2)27, and to examine the association between blood pressure and plasma renin-angiotensin parameters during the conscious state. Two litters of heterozygous TGR(mREN2)27 rats and their normotensive Sprague-Dawley reference animals were bred in our laboratory. Cardiovascular phenotypes and blood, for the evaluation of plasma renin-angiotensin-system parameters, were obtained via arterial catheters in conscious rats 4 weeks after birth. Blood pressure values showed a high degree of interindividual variability and significant litter differences in the group of transgenic animals ranging from normotensive tohypertensive values. Plasma prorenin levels were markedly increased in TGR(mREN2)27, whereas both active renin and angiotensin II plasma concentrations were reduced independently from hypertension. Plasma prorenin levels in litter 2 of transgenic animals which exhibited significantly elevated blood pressures were significantly higher as compared to those of litter 1 which showed blood pressures that were not significantly different from SD. These data demonstrate that the development of hypertension in heterozygous TGR(mREN2)27 takes place in the fourth week of postnatal life and exhibits large interindividual variability. Moreover, development of early hypertension in young heterozygous TGR(mREN2)27 is associated with higher plasma prorenin levels.
Authors:
R Kreutz; M S Fernandez-Alfonso; M Paul; J Peters
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  20     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-82     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Nephrology, University Hospital Benjamin Franklin, Freie Universität, Berlin, Germany. kreutz@ukbf.fu-berlin.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified / genetics*
Blood Pressure / physiology
Enzyme Precursors / blood
Heterozygote*
Hypertension / blood,  genetics*,  physiopathology*
Male
Mice
Rats
Rats, Sprague-Dawley
Renin / blood,  genetics*
Chemical
Reg. No./Substance:
0/Enzyme Precursors; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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