| Differential development of early hypertension in heterozygous transgenic TGR(mREN2)27 rats. | |
MedLine Citation:
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PMID: 9605382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to determine blood pressures in young heterozygous transgenic rats harbouring the Ren-2 mouse gene, TGR(mREN2)27, and to examine the association between blood pressure and plasma renin-angiotensin parameters during the conscious state. Two litters of heterozygous TGR(mREN2)27 rats and their normotensive Sprague-Dawley reference animals were bred in our laboratory. Cardiovascular phenotypes and blood, for the evaluation of plasma renin-angiotensin-system parameters, were obtained via arterial catheters in conscious rats 4 weeks after birth. Blood pressure values showed a high degree of interindividual variability and significant litter differences in the group of transgenic animals ranging from normotensive tohypertensive values. Plasma prorenin levels were markedly increased in TGR(mREN2)27, whereas both active renin and angiotensin II plasma concentrations were reduced independently from hypertension. Plasma prorenin levels in litter 2 of transgenic animals which exhibited significantly elevated blood pressures were significantly higher as compared to those of litter 1 which showed blood pressures that were not significantly different from SD. These data demonstrate that the development of hypertension in heterozygous TGR(mREN2)27 takes place in the fourth week of postnatal life and exhibits large interindividual variability. Moreover, development of early hypertension in young heterozygous TGR(mREN2)27 is associated with higher plasma prorenin levels. |
Authors:
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R Kreutz; M S Fernandez-Alfonso; M Paul; J Peters |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 20 ISSN: 1064-1963 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-27 Completed Date: 1998-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-82 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Nephrology, University Hospital Benjamin Franklin, Freie Universität, Berlin, Germany. kreutz@ukbf.fu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified / genetics* Blood Pressure / physiology Enzyme Precursors / blood Heterozygote* Hypertension / blood, genetics*, physiopathology* Male Mice Rats Rats, Sprague-Dawley Renin / blood, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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