Document Detail

Differential cytokine profile in children with cystic fibrosis.
MedLine Citation:
PMID:  15885645     Owner:  NLM     Status:  MEDLINE    
The previously observed occurrence of antineutrophil cytoplasmic autoantibodies (ANCA) in patients who have cystic fibrosis (CF), together with the reported decrease in IgG2, a Th1-controlled isotype, suggests a potential for Th1/Th2 imbalance in CF patients with a possible Th2 predominance. 48 CF patients and 16 controls had levels of IFNgamma, IL-4, and IL-10 measured in supernatants of whole blood cell cultures stimulated by lipopolysaccharide (LPS) and phytohemaglutinine (PHA). The patients were divided into 2 groups: "low responders", having negligible secretion of cytokines (IFNgamma: 10.0-200.0 pg/ml, IL-4: 0.0-0.3 pg/ml) and "high responders", producing high levels of both IFNgamma (500.0-2000.0 pg/ml) and IL-4 (1.0-200.0 pg/ml). There was a statistically significant (P < 0.01) deterioration of lung function measured by an FEV(1) decline by 11.2% over 3 years in the "low responder" group. 10 of 16 "low responders" had chronic lung infections with P. aeruginosa while such infection was less prevalent in the "high responder" group where only 13 of 32 CF patients had positive cultures. A shift towards Th2 response was observed in the "high responder" group as children chronically infected with P. aeruginosa had greater IL-4 production than non-infected CF patients within the same cohort. ANCA autoantibodies were found only in the "high responder" group. Th2 immune response predominance in a subset of CF patients is associated with chronic P. aeruginosa infection.
Jitka Brazova; Anna Sediva; Dagmara Pospisilova; Vera Vavrova; Petr Pohunek; Milan Macek; Jirina Bartunkova; Hynek Lauschmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  115     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-06-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-5     Citation Subset:  IM    
Institute of Immunology, University Hospital Motol, Prague, Czech Republic.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / biosynthesis
Case-Control Studies
Child, Preschool
Cystic Fibrosis / immunology*,  microbiology,  physiopathology
Immunoglobulin Isotypes / blood
Interferon-gamma / blood*
Interleukin-10 / blood*
Interleukin-4 / blood*
Pseudomonas Infections / epidemiology,  immunology*,  physiopathology
Respiratory Function Tests
Th2 Cells / immunology
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Immunoglobulin Isotypes; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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