Document Detail

Differential cyclin D1 requirements of proliferating Schwann cells during development and after injury.
MedLine Citation:
PMID:  11749035     Owner:  NLM     Status:  MEDLINE    
Neurons regulate Schwann cell proliferation, but little is known about the molecular basis of this interaction. We have examined the possibility that cyclin D1 is a key regulator of the cell cycle in Schwann cells. Myelinating Schwann cells express cyclin D1 in the perinuclear region, but after axons are severed, cyclin D1 is strongly upregulated in parallel with Schwann cell proliferation and translocates into Schwann cell nuclei. During development, cyclin D1 expression is confined to the perinuclear region of proliferating Schwann cells and the analysis of cyclin D1-null mice indicates that cyclin D1 is not required for this type of Schwann cell proliferation. As in the adult, injury to immature peripheral nerves leads to translocation of cyclin D1 to Schwann cell nuclei and injury-induced proliferation is impaired in both immature and mature cyclin D1-deficient Schwann cells. Thus, our data indicate that the molecular mechanisms regulating proliferation of Schwann cells during development or activated by axonal damage are fundamentally different.
S Atanasoski; S Shumas; C Dickson; S S Scherer; U Suter
Related Documents :
2636995 - Normal neuronal features of the human gallbladder and structural changes in cholelithia...
9096765 - Diagnosis of cmt1a duplications and hnpp deletions by interphase fish: implications for...
19486305 - Usefulness of sural nerve biopsy in the genomic era.
3201925 - Proliferation of rat intraspinal schwann cells following tellurium intoxication.
20520745 - Microspectroscopy of spectral biomarkers associated with human corneal stem cells.
21541475 - Catalytic lectin (leczyme) from bullfrog (rana catesbeiana) eggs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  18     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-92     Citation Subset:  IM    
Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / physiology
Animals, Newborn
Cell Compartmentation / physiology
Cell Differentiation / physiology
Cell Division / physiology*
Cell Nucleus / metabolism,  ultrastructure
Cells, Cultured
Cyclin D1 / deficiency*,  genetics
Cytoplasm / metabolism,  ultrastructure
Gene Expression Regulation / physiology
Mice, Inbred C57BL
Mice, Knockout
Myelin Sheath / genetics,  metabolism
Nerve Crush
Nerve Regeneration / physiology*
Peripheral Nerves / growth & development*,  injuries,  metabolism*
Rats, Inbred Strains
Schwann Cells / cytology,  metabolism*
Sciatic Nerve / growth & development,  injuries,  metabolism
Wallerian Degeneration / metabolism*,  physiopathology
Reg. No./Substance:
136601-57-5/Cyclin D1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pseudotumour cerebri occurring in association with the Chiari malformation.
Next Document:  Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes.