Document Detail


Differential cyclin D1 requirements of proliferating Schwann cells during development and after injury.
MedLine Citation:
PMID:  11749035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons regulate Schwann cell proliferation, but little is known about the molecular basis of this interaction. We have examined the possibility that cyclin D1 is a key regulator of the cell cycle in Schwann cells. Myelinating Schwann cells express cyclin D1 in the perinuclear region, but after axons are severed, cyclin D1 is strongly upregulated in parallel with Schwann cell proliferation and translocates into Schwann cell nuclei. During development, cyclin D1 expression is confined to the perinuclear region of proliferating Schwann cells and the analysis of cyclin D1-null mice indicates that cyclin D1 is not required for this type of Schwann cell proliferation. As in the adult, injury to immature peripheral nerves leads to translocation of cyclin D1 to Schwann cell nuclei and injury-induced proliferation is impaired in both immature and mature cyclin D1-deficient Schwann cells. Thus, our data indicate that the molecular mechanisms regulating proliferation of Schwann cells during development or activated by axonal damage are fundamentally different.
Authors:
S Atanasoski; S Shumas; C Dickson; S S Scherer; U Suter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular neurosciences     Volume:  18     ISSN:  1044-7431     ISO Abbreviation:  Mol. Cell. Neurosci.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100095     Medline TA:  Mol Cell Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-92     Citation Subset:  IM    
Affiliation:
Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Animals, Newborn
Cell Compartmentation / physiology
Cell Differentiation / physiology
Cell Division / physiology*
Cell Nucleus / metabolism,  ultrastructure
Cells, Cultured
Cyclin D1 / deficiency*,  genetics
Cytoplasm / metabolism,  ultrastructure
Gene Expression Regulation / physiology
Immunohistochemistry
Mice
Mice, Inbred C57BL
Mice, Knockout
Myelin Sheath / genetics,  metabolism
Nerve Crush
Nerve Regeneration / physiology*
Peripheral Nerves / growth & development*,  injuries,  metabolism*
Rats
Rats, Inbred Strains
Schwann Cells / cytology,  metabolism*
Sciatic Nerve / growth & development,  injuries,  metabolism
Wallerian Degeneration / metabolism*,  physiopathology
Chemical
Reg. No./Substance:
136601-57-5/Cyclin D1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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