Document Detail

Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals.
MedLine Citation:
PMID:  15710878     Owner:  NLM     Status:  MEDLINE    
Although dependent on the integrity of a central pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN), endogenous daily (circadian) rhythms are expressed in a wide variety of peripheral organs. The pathways by which the pacemaker controls the periphery are unclear. Here, we used parabiosis between intact and SCN-lesioned mice to show that nonneural (behavioral or bloodborne) signals are adequate to maintain circadian rhythms of clock gene expression in liver and kidney, but not in heart, spleen, or skeletal muscle. These results indicate that the SCN regulates expression of circadian oscillations in different peripheral organs by diverse pathways.
Hongnian Guo; Judy McKinley Brewer; Ameya Champhekar; Ruth B S Harris; Eric L Bittman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2005-02-14
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-03-24     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3111-6     Citation Subset:  IM    
Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA.
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MeSH Terms
Circadian Rhythm / physiology*
Gene Expression
Kidney / metabolism
Liver / metabolism
Mice, Inbred C57BL
Suprachiasmatic Nucleus / physiology*
Grant Support
R01 059166//PHS HHS

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