| Differential connexin distribution accommodates cardiac function in different species. | |
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MedLine Citation:
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PMID: 8534903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using immunohistochemical staining, the distribution of connexin40 (Cx40) and connexin43 (Cx43) was studied in rat, guinea pig, porcine, bovine and human hearts. These species display differences in the degree of morphological differentiation of the conduction system. This study was performed in the anticipation that comparison of the distributions of Cx40 and Cx43 in young and adult specimens may provide clues as to the physiological role of connexins in the heart. To a large extent, the distribution patterns of Cx40 and Cx43 are comparable between species. In neonates and adults, Cx43 was immunolocalized throughout the working myocardium, but in the conduction system Cx43 was detected only after birth. Cx40 was found to appear slightly earlier in development than Cx43 and to disappear when levels of Cx43 became more abundant. This time course was seen in working myocardium and in the ventricular conduction system. Together these data suggest that expression of Cx40 induces or facilitates expression of Cx43, while abundant expression of Cx43 in turn leads to suppression of Cx40 expression. The exceptions to this may represent blocks in this potential regulatory sequence. A second conclusion is that Cx40 and Cx43 containing gap junctions appear in the ventricular conduction system from distal to proximal and only after birth. This indicates that terminal differentiation of the conduction system occurs unexpectedly late in development. |
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Authors:
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M J van Kempen; I ten Velde; A Wessels; P W Oosthoek; D Gros; H J Jongsma; A F Moorman; W H Lamers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microscopy research and technique Volume: 31 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-02-05 Completed Date: 1996-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 420-36 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Embryology, University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Animals, Newborn Cattle Cell Communication Connexin 43 / metabolism* Connexins / metabolism* Female Fluorescent Antibody Technique Gap Junctions / metabolism* Guinea Pigs Heart / physiology* Heart Conduction System / metabolism Humans Immunoenzyme Techniques Infant, Newborn Male Myocardium / cytology, metabolism* Rats Rats, Wistar Species Specificity Swine |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43; 0/Connexins; 0/connexin 40 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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