Document Detail


Differential channelling of liver lipids in relation to susceptibility to hepatic steatosis in two species of ducks.
MedLine Citation:
PMID:  12892758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the human, hepatic steatosis can be associated with an imbalance between synthesis, secretion and storage of hepatic lipids, and exhibits a genetic susceptibility. The effect of overfeeding on hepatic lipid channelling was investigated in two genotypes of ducks that differ in their susceptibility to fatty liver, i.e. the common duck, Anas platyrhynchos, and the Muscovy duck, Cairina moschata. Before overfeeeding, the Muscovy duck exhibited a lower subcutaneous adiposity and a higher muscular development, whereas hepatic composition was similar in both genotypes (>5% lipids and triglycerides accounting for 6-10% lipids). In the plasma lipoprotein profile, HDL predominated (5.5-7.8 g/l) over VLDL (0.09-0.25 g/l) and LDL (0.65-1.06 g/l). All lipid and lipoprotein concentrations were lower in the Muscovy duck. In response to overfeeding, the Muscovy duck exhibited a higher degree of hepatic steatosis (62 vs. 50% lipids), and a lower increase in adiposity and in the concentration of plasma triglycerides (6-fold vs. 10-fold) and VLDL (23-fold vs. 34-fold). Thus, certain genotypes may be more responsive to the dietary induction of fatty liver because of a less efficient channelling of hepatic lipids towards secretion into plasma and adipose storage, and the duck may represent a suitable model in which to study the development of hepatic steatosis and its pathogenesis.
Authors:
Dominique Hermier; Gérard Guy; Solange Guillaumin; Stéphane Davail; Jean-Marc André; Robert Hoo-Paris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology     Volume:  135     ISSN:  1096-4959     ISO Abbreviation:  Comp. Biochem. Physiol. B, Biochem. Mol. Biol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2004-04-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9516061     Medline TA:  Comp Biochem Physiol B Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-75     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie de la Nutrition-INRA, Bâtiment 447, Centre Scientifique d'Orsay, Orsay 91405, France. dominique.hermier@ibaic.u-psud.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Diet
Disease Susceptibility
Ducks / physiology*
Fatty Liver / genetics,  metabolism*
Genotype
Humans
Lipid Metabolism*
Lipoproteins / blood
Liver / chemistry,  metabolism*,  pathology
Male
Muscle, Skeletal / chemistry,  metabolism
Organ Size
Chemical
Reg. No./Substance:
0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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