Document Detail


Differential changes in the cellular composition of the developing marsupial brain.
MedLine Citation:
PMID:  23322491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Throughout development both the body and the brain change at remarkable rates. Specifically, the number of cells in the brain undergoes dramatic nonlinear changes, first exponentially increasing in cell number and then decreasing in cell number. Different cell types, such as neurons and glia, undergo these changes at different stages of development. The current investigation used the isotropic fractionator method to examine the changes in cellular composition at multiple developmental milestones in the short-tailed opossum, Monodelphis domestica. Here we report several novel findings concerning marsupial brain development and organization. First, during the later stages of neurogenesis (P18), neurons make up most of the cells in the neocortex, although the total number of neurons remains the same throughout the life span. In contrast, in the subcortical regions, the number of neurons decreases dramatically after P18, and a converse relationship is observed for nonneuronal cells. In the cerebellum, the total number of cells gradually increases until P180 and then remains constant, and then the number of neurons is consistent across the developmental ages examined. For the three major structures examined, neuronal density and the percentage of neurons within a structure are highest during neurogenesis and then decrease after this point. Finally, the total number of neurons in the opossum brain is relatively low compared with other small-brained mammals such as mice. The relatively low number of neurons and correspondingly high number of nonneurons suggests that in the marsupial brain nonneurons may play a significant role in signal processing.
Authors:
Adele M H Seelke; James C Dooley; Leah A Krubitzer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  521     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-05     Completed Date:  2014-01-13     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2602-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Brain / cytology,  growth & development*
Cell Count
Cell Nucleus / ultrastructure
Cerebellum / growth & development,  physiology
Fluorescent Dyes
Immunohistochemistry
Indoles
Neocortex / growth & development,  physiology
Opossums / growth & development*
Tissue Fixation
Grant Support
ID/Acronym/Agency:
R01 EY022987/EY/NEI NIH HHS; R21 NS071225/NS/NINDS NIH HHS; R21NS071225/NS/NINDS NIH HHS; T32EY015387/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 0/Indoles; 47165-04-8/DAPI
Comments/Corrections

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