| Differential changes in the cellular composition of the developing marsupial brain. | |
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MedLine Citation:
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PMID: 23322491 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Throughout development both the body and the brain change at remarkable rates. Specifically, the number of cells in the brain undergoes dramatic non-linear changes; first exponentially increasing in cell number and then decreasing in cell number. Importantly, different cell types, such as neurons and glia, undergo these changes at different stages of development. In the current investigation we used the isotropic fractionator method to examine the changes in cellular composition at multiple developmental milestones in the short-tailed opossum, Monodelphis domestica. Here we report several novel findings concerning marsupial brain development and organization. First, during the later stages of neurogenesis (P18) neurons comprise most of the cells in the neocortex, although the total number of neurons remains the same throughout the lifespan. In contrast, in the subcortical regions the number of neurons decreases dramatically after P18, and a converse relationship is observed for non-neuronal cells. In the cerebellum, the total number of cells gradually increases until P180 and then remains constant, and then the number of neurons is consistent across the developmental ages examined. For the three major structures examined, neuronal density and the percent of neurons within a structure is highest during neurogenesis and then decreases after this time point. Finally, the total number of neurons in the opossum brain is relatively low compared to other small-brained mammals such as mice. The relatively low number of neurons and correspondingly high number of non-neurons suggests that in the marsupial brain non-neurons may play a significant role in signal processing. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc. |
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Authors:
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Adele M H Seelke; James C Dooley; Leah A Krubitzer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: The Journal of comparative neurology Volume: - ISSN: 1096-9861 ISO Abbreviation: J. Comp. Neurol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Wiley Periodicals, Inc. |
Affiliation:
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Center for Neuroscience and USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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