| Differential cardiovascular effects mediated by mu and kappa opiate receptors in hindbrain nuclei. | |
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MedLine Citation:
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PMID: 6318199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To further investigate the role of opioid peptides and specific opiate receptor subtypes in central cardiovascular regulation by hindbrain nuclei, mu (D-Ala2,MePhe4,Gly-ol5 enkephalin, DAGO), delta (D-Ala2,D-Leu5 enkephalin, DADL) or kappa (MRZ 2549) agonists were microinjected into hindbrain nuclei of spontaneously or artificially respired, pentobarbital-anesthetized rats. In the nucleus tractus solitarius (NTS), DAGO and DADL (0.3 nmol) elicited pressor responses and tachycardia. MRZ (3.0-16 nmol) depressed blood pressure in spontaneously breathing rats, but accelerated heart rate in artificially ventilated animals. Blood pressure and heart rate of spontaneously breathing animals were not altered following nucleus ambiguus (NA) injection of DAGO or DADL (0.3 nmol), but were elevated in artificially respired animals; MRZ (3.0-10 nmol) injected into the NA depressed blood pressure in both groups. These data suggest that in the absence of respiratory depression, NTS and NA mu receptors mediate pressor responses and tachycardia; kappa receptors in the NA mediate a decrease in blood pressure but cardioacceleration in the NTS. |
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Authors:
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A H Hassen; G Feuerstein; A I Faden |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Peptides Volume: 4 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1983 Sep-Oct |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 621-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Brain Stem / drug effects, physiology* Heart Rate / drug effects* Male Naloxone / pharmacology Narcotics / pharmacology* Rats Rats, Inbred Strains Receptors, Opioid / drug effects, physiology* Receptors, Opioid, kappa Receptors, Opioid, mu Respiration / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 0/Receptors, Opioid; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 465-65-6/Naloxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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