Document Detail


Differential brainstem Fos-like immunoreactivity after laryngeal-induced coughing and its reduction by codeine.
MedLine Citation:
PMID:  9364079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used the expression of the immediate-early gene c-fos, a marker of neuronal activation, to localize brainstem neuronal populations functionally related to fictive cough (FC). In decerebrate, paralyzed, and ventilated cats, the level of Fos-like immunoreactivity (FLI) was examined in five groups of animals: (1) controls, sham-operated unstimulated animals; (2) coughing cats, including both animals in which FC was elicited by unilateral electrical stimulation of the superior laryngeal nerve (SLN) and (3) those in which FC was elicited by bilateral SLN stimulation; (4) stimulated-treated cats, in which bilateral SLN stimulation was applied after selective blockade of FC by codeine; and (5) codeine controls, sham-operated unstimulated cats subjected to administration of codeine. Fifteen brainstem structures were compared for numbers of labeled cells. Because codeine selectively blocks FC, brainstem nuclei activated specifically during FC were identified as regions showing increased FLI after FC and significant reductions in FLI after FC suppression by codeine in stimulated-treated cats. In coughing animals, we observed a selective immunoreactivity in the interstitial and ventrolateral subdivisions of the nucleus of the tractus solitarius, the medial part of the lateral tegmental field, the internal division of the lateral reticular nucleus, the nucleus retroambiguus, the para-ambigual region, the retrofacial nucleus, and the medial parabrachial nucleus. FLI in all these nuclei was significantly reduced in stimulated-treated cats. Our results are consistent with the involvement of neurons overlapping the main brainstem respiratory-related regions as well as the lateral tegmental field and the lateral reticular nucleus in the neural processing of laryngeal-induced FC.
Authors:
C Gestreau; A L Bianchi; L Grélot
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  17     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1997-12-15     Completed Date:  1997-12-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9340-52     Citation Subset:  IM    
Affiliation:
Département de Physiologie et Neurophysiologie, Centre National de la Recherche Scientifique Unité de Recherche Associée 1832, Faculté des Sciences et Techniques Saint Jérôme, 13397 Marseille Cedex 20, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antitussive Agents / pharmacology,  therapeutic use*
Biological Markers
Brain Mapping
Brain Stem / metabolism,  pathology*,  physiopathology
Bronchoconstriction / drug effects,  physiology
Cats
Codeine / pharmacology,  therapeutic use*
Cough / drug therapy,  physiopathology*
Cranial Nerves / physiopathology
Decerebrate State
Electric Stimulation
Female
Gene Expression Regulation / drug effects
Genes, Immediate-Early* / drug effects
Genes, fos* / drug effects
Hemodynamics / drug effects
Laryngeal Nerves / physiopathology*
Male
Neurons / metabolism*,  pathology
Proto-Oncogene Proteins c-fos / biosynthesis*,  genetics
Tegmentum Mesencephali / pathology,  physiopathology
Chemical
Reg. No./Substance:
0/Antitussive Agents; 0/Biological Markers; 0/Proto-Oncogene Proteins c-fos; 76-57-3/Codeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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