| Differential brainstem Fos-like immunoreactivity after laryngeal-induced coughing and its reduction by codeine. | |
| | |
MedLine Citation:
|
PMID: 9364079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We used the expression of the immediate-early gene c-fos, a marker of neuronal activation, to localize brainstem neuronal populations functionally related to fictive cough (FC). In decerebrate, paralyzed, and ventilated cats, the level of Fos-like immunoreactivity (FLI) was examined in five groups of animals: (1) controls, sham-operated unstimulated animals; (2) coughing cats, including both animals in which FC was elicited by unilateral electrical stimulation of the superior laryngeal nerve (SLN) and (3) those in which FC was elicited by bilateral SLN stimulation; (4) stimulated-treated cats, in which bilateral SLN stimulation was applied after selective blockade of FC by codeine; and (5) codeine controls, sham-operated unstimulated cats subjected to administration of codeine. Fifteen brainstem structures were compared for numbers of labeled cells. Because codeine selectively blocks FC, brainstem nuclei activated specifically during FC were identified as regions showing increased FLI after FC and significant reductions in FLI after FC suppression by codeine in stimulated-treated cats. In coughing animals, we observed a selective immunoreactivity in the interstitial and ventrolateral subdivisions of the nucleus of the tractus solitarius, the medial part of the lateral tegmental field, the internal division of the lateral reticular nucleus, the nucleus retroambiguus, the para-ambigual region, the retrofacial nucleus, and the medial parabrachial nucleus. FLI in all these nuclei was significantly reduced in stimulated-treated cats. Our results are consistent with the involvement of neurons overlapping the main brainstem respiratory-related regions as well as the lateral tegmental field and the lateral reticular nucleus in the neural processing of laryngeal-induced FC. |
| | |
Authors:
|
C Gestreau; A L Bianchi; L Grélot |
Related Documents
:
|
12520409 - Activation of brain stem neurons by irritant chemical stimulation of the throat assesse... 15519689 - Exposure to hexanal odor induces extraordinary fos expression in the medial preoptic ar... 12399119 - Immediate early gene expression in the visual cortex of normal and dark reared cats: di... 7771599 - Rat vasopressin cell responses to simulated hemorrhage: stimulus-dependent role for a1 ... 17100849 - Novel temporal configurations of stimuli produce discrete changes in immediate-early ge... 10235679 - Vomeronasal neuroepithelium and forebrain fos responses to male pheromones in male and ... 3722439 - Second somatic sensory cortical area (sii) in a prosimian primate, galago crassicaudatus. 2320209 - Pericyte degeneration and thickening of basement membranes of cerebral microvessels in ... 7753499 - Studies of the respiratory center using isolated brainstem-spinal cord preparations. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 17 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1997 Dec |
Date Detail:
|
Created Date: 1997-12-15 Completed Date: 1997-12-15 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 9340-52 Citation Subset: IM |
Affiliation:
|
Département de Physiologie et Neurophysiologie, Centre National de la Recherche Scientifique Unité de Recherche Associée 1832, Faculté des Sciences et Techniques Saint Jérôme, 13397 Marseille Cedex 20, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antitussive Agents / pharmacology, therapeutic use* Biological Markers Brain Mapping Brain Stem / metabolism, pathology*, physiopathology Bronchoconstriction / drug effects, physiology Cats Codeine / pharmacology, therapeutic use* Cough / drug therapy, physiopathology* Cranial Nerves / physiopathology Decerebrate State Electric Stimulation Female Gene Expression Regulation / drug effects Genes, Immediate-Early* / drug effects Genes, fos* / drug effects Hemodynamics / drug effects Laryngeal Nerves / physiopathology* Male Neurons / metabolism*, pathology Proto-Oncogene Proteins c-fos / biosynthesis*, genetics Tegmentum Mesencephali / pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Antitussive Agents; 0/Biological Markers; 0/Proto-Oncogene Proteins c-fos; 76-57-3/Codeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detectability index measures of binaural masking level difference across populations of inferior col...
Next Document: Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-...