| Differential brain responses to cries of infants with autistic disorder and typical development: an fMRI study. | |
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MedLine Citation:
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PMID: 22835685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study used fMRI to measure brain activity during adult processing of cries of infants with autistic disorder (AD) compared to cries of typically developing (TD) infants. Using whole brain analysis, we found that cries of infants with AD compared to those of TD infants elicited enhanced activity in brain regions associated with verbal and prosodic processing, perhaps because altered acoustic patterns of AD cries render them especially difficult to interpret, and increased activity in brain regions associated with emotional processing, indicating that AD cries also elicit more negative feelings and may be perceived as more aversive and/or arousing. Perceived distress engendered by AD cries related to increased activation in brain regions associated with emotional processing. This study supports the hypothesis that cry is an early and meaningful anomaly displayed by children with AD. It could be that cries associated with AD alter parent-child interactions much earlier than the time that reliable AD diagnosis normally occurs. |
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Authors:
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Paola Venuti; Andrea Caria; Gianluca Esposito; Nicola De Pisapia; Marc H Bornstein; Simona de Falco |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2012-07-24 |
Journal Detail:
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Title: Research in developmental disabilities Volume: 33 ISSN: 1873-3379 ISO Abbreviation: Res Dev Disabil Publication Date: 2012 Nov-Dec |
Date Detail:
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Created Date: 2012-09-03 Completed Date: 2013-03-29 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 8709782 Medline TA: Res Dev Disabil Country: United States |
Other Details:
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Languages: eng Pagination: 2255-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cognitive Science and Education, University of Trento, Trento, Italy. paola.venuti@unitn.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arousal / physiology Attitude Auditory Perception / physiology* Autistic Disorder / diagnosis, physiopathology* Brain / physiopathology* Brain Mapping Cerebral Cortex / physiopathology Crying / physiology* Dominance, Cerebral / physiology Female Frontal Lobe / physiopathology Humans Image Interpretation, Computer-Assisted* Infant Magnetic Resonance Imaging* Male Sound Spectrography Temporal Lobe / physiopathology Thalamus / physiology |
| Grant Support | |
ID/Acronym/Agency:
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ZIA HD001119-25/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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