Document Detail


Differential brain responses to cries of infants with autistic disorder and typical development: an fMRI study.
MedLine Citation:
PMID:  22835685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study used fMRI to measure brain activity during adult processing of cries of infants with autistic disorder (AD) compared to cries of typically developing (TD) infants. Using whole brain analysis, we found that cries of infants with AD compared to those of TD infants elicited enhanced activity in brain regions associated with verbal and prosodic processing, perhaps because altered acoustic patterns of AD cries render them especially difficult to interpret, and increased activity in brain regions associated with emotional processing, indicating that AD cries also elicit more negative feelings and may be perceived as more aversive and/or arousing. Perceived distress engendered by AD cries related to increased activation in brain regions associated with emotional processing. This study supports the hypothesis that cry is an early and meaningful anomaly displayed by children with AD. It could be that cries associated with AD alter parent-child interactions much earlier than the time that reliable AD diagnosis normally occurs.
Authors:
Paola Venuti; Andrea Caria; Gianluca Esposito; Nicola De Pisapia; Marc H Bornstein; Simona de Falco
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2012-07-24
Journal Detail:
Title:  Research in developmental disabilities     Volume:  33     ISSN:  1873-3379     ISO Abbreviation:  Res Dev Disabil     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-09-03     Completed Date:  2013-03-29     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8709782     Medline TA:  Res Dev Disabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2255-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Cognitive Science and Education, University of Trento, Trento, Italy. paola.venuti@unitn.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / physiology
Attitude
Auditory Perception / physiology*
Autistic Disorder / diagnosis,  physiopathology*
Brain / physiopathology*
Brain Mapping
Cerebral Cortex / physiopathology
Crying / physiology*
Dominance, Cerebral / physiology
Female
Frontal Lobe / physiopathology
Humans
Image Interpretation, Computer-Assisted*
Infant
Magnetic Resonance Imaging*
Male
Sound Spectrography
Temporal Lobe / physiopathology
Thalamus / physiology
Grant Support
ID/Acronym/Agency:
ZIA HD001119-25/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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