Document Detail

Differential brain activation during facial emotion discrimination in first-episode schizophrenia.
MedLine Citation:
PMID:  19056093     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aberrant brain activation during facial emotion discrimination has been described in chronic schizophrenia, while little is known about early stages of the illness. The aim of the current study was to investigate valence-specific brain activation of emotion discrimination in first-episode schizophrenia. These patients provide the advantage of lacking the effects of long-term medication and chronic illness course and can hence further enhance the understanding of underlying psychopathological mechanisms. METHODS: Using event-related fMRI, we investigated 18 first-episode schizophrenia patients and 18 matched healthy subjects during an explicit emotion discrimination task presenting happy, sad and neutral monochromatic facial expressions. A repeated measure analysis of variance (ANOVA) with the factors Group (patients, healthy subjects), Gender and Emotion (happy, sad, neutral) was performed on behavioural and functional data. RESULTS: Behavioural performance did not differ between groups. Valence-independent hypoactivations in patients were observed for the anterior cingulate and orbitofrontal cortex while hyperactivations emerged in the posterior cingulate and the precuneus. Emotion-specific group differences were revealed in inferior parietal and orbitofrontal brain areas and the hippocampus. CONCLUSIONS: First-episode schizophrenia already affects areas involved in processing of both, emotions and primary facial information. Our study underlines the role of dysfunctional neural networks as the basis of disturbed social interactions in early schizophrenia.
Martina Reske; Ute Habel; Thilo Kellermann; Volker Backes; N Jon Shah; Martina von Wilmsdorff; Wolfgang Gaebel; Karl Zilles; Frank Schneider
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2008-12-04
Journal Detail:
Title:  Journal of psychiatric research     Volume:  43     ISSN:  0022-3956     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-06     Completed Date:  2009-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  592-9     Citation Subset:  IM    
Department of Psychiatry, University of California San Diego, 8939 Villa La Jolla Drive, Suite C230, La Jolla, San Diego, CA 92037, USA.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Brain / drug effects,  physiopathology*
Brain Mapping / methods
Discrimination (Psychology)*
Echo-Planar Imaging / methods
Facial Expression*
Haloperidol / therapeutic use
Imaging, Three-Dimensional / methods
Magnetic Resonance Imaging / methods
Nerve Net / physiopathology*
Psychiatric Status Rating Scales / statistics & numerical data
Risperidone / therapeutic use
Schizophrenia / diagnosis,  drug therapy,  physiopathology*
Task Performance and Analysis
Young Adult
Reg. No./Substance:
0/Antipsychotic Agents; 106266-06-2/Risperidone; 52-86-8/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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