Document Detail

Differential beta adrenergic sensitivity of atrial and ventricular tissue assessed by chronotropic, inotropic, and cyclic AMP responses to isoprenaline and dobutamine.
MedLine Citation:
PMID:  182368     Owner:  NLM     Status:  MEDLINE    
Cat atrial tissue was more sensitive to isoprenaline (USP:isoproterenol) and dobutamine than ventricular tissue. Chronotropic response of atrial strips occurred at lower agonist concentrations than inotropic responses of papillary muscle. Cyclic AMP responses in atrial slices also occurred at lower agonist concentrations and were of much greater magnitude than the cyclic AMP responses in ventricular slices. However, the disporportionately greater sensitivity of atrial tissue was more marked with isoprenaline than with dobutamine.
R R Tuttle; C C Hillmann; R E Toomey
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  10     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-10-29     Completed Date:  1976-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  452-8     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Catecholamines / pharmacology*
Cyclic AMP / metabolism*
Dobutamine / pharmacology*
Heart Atria / drug effects*,  innervation*,  metabolism
Heart Ventricles / drug effects*,  innervation*,  metabolism
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects*
Papillary Muscles / drug effects
Receptors, Adrenergic / drug effects*
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 34368-04-2/Dobutamine; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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