| Differential beta adrenergic sensitivity of atrial and ventricular tissue assessed by chronotropic, inotropic, and cyclic AMP responses to isoprenaline and dobutamine. | |
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MedLine Citation:
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PMID: 182368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cat atrial tissue was more sensitive to isoprenaline (USP:isoproterenol) and dobutamine than ventricular tissue. Chronotropic response of atrial strips occurred at lower agonist concentrations than inotropic responses of papillary muscle. Cyclic AMP responses in atrial slices also occurred at lower agonist concentrations and were of much greater magnitude than the cyclic AMP responses in ventricular slices. However, the disporportionately greater sensitivity of atrial tissue was more marked with isoprenaline than with dobutamine. |
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Authors:
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R R Tuttle; C C Hillmann; R E Toomey |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 10 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1976-10-29 Completed Date: 1976-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 452-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Catecholamines / pharmacology* Cats Cyclic AMP / metabolism* Dobutamine / pharmacology* Female Heart Atria / drug effects*, innervation*, metabolism Heart Ventricles / drug effects*, innervation*, metabolism Isoproterenol / pharmacology* Male Myocardial Contraction / drug effects* Papillary Muscles / drug effects Receptors, Adrenergic / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Receptors, Adrenergic; 34368-04-2/Dobutamine; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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