| Differential association of tumour necrosis factor-alpha single nucleotide polymorphism (-308) with tuberculosis and bronchial asthma. | |
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MedLine Citation:
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PMID: 19004142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tumour necrosis factor (TNF)-alpha is a pleiotropic, pro-inflammatory cytokine of 17 kDa, whose gene is localized on the short arm of chromosome 6. It has a G-308A polymorphism in the promoter region, which is known to be associated with its differential production; the A allele being the high producer. The circulating level of TNF-alpha is under genetic control and implicated in the pathophysiology of asthma and tuberculosis. Since raised levels of TNF-alpha have been found in asthma and tuberculosis, we looked for the association of TNF-alpha G-308A polymorphism in patients with these diseases. METHODS: A total of 300 blood samples from patients (155 with asthma, 145 tuberculosis) and 211 normal healthy controls were collected. The G-308A polymorphism was studied using amplification refractory mutation system analysis. RESULTS: The distribution of G/A alleles in the two patient groups when compared with normal controls revealed a statistically significant association with asthma (p = 0.016) but not with tuberculosis (p = 0.178). CONCLUSION: The data support the common variant common disease hypothesis, which emphasizes that common genetic variations may participate as critical players in inciting common diseases. |
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Authors:
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Vijay Kumar; Rajiv Khosla; Vikas Gupta; B C Sarin; P K Sehajpal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The National medical journal of India Volume: 21 ISSN: 0970-258X ISO Abbreviation: Natl Med J India Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-11-13 Completed Date: 2009-01-06 Revised Date: 2009-07-30 |
Medline Journal Info:
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Nlm Unique ID: 8809315 Medline TA: Natl Med J India Country: India |
Other Details:
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Languages: eng Pagination: 120-2 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Alleles Asthma / genetics* Child Child, Preschool Chromosomes, Human, Pair 6 / genetics Female Genotype Humans Male Middle Aged Polymorphism, Single Nucleotide* Promoter Regions, Genetic / genetics Tuberculosis / genetics* Tumor Necrosis Factor-alpha / genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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