Document Detail

Differential appetite-related responses to central neuropeptide S in lines of chickens divergently selected for low or high body weight.
MedLine Citation:
PMID:  18445129     Owner:  NLM     Status:  MEDLINE    
The anorexigenic 20 amino acid neuropeptide S (NPS) has not been studied in an animal model of hypo- or hyperphagia. The present study aimed to elucidate whether central NPS appetite-related effects are different in lines of chickens that had undergone long-term divergent selection for low (LWS) or high (HWS) body weight and that were hypo- and hyperphagic, respectively. It took a longer time for food intake to be reduced in LWS than HWS chicks administered the lowest dose of NPS tested (0.14 nmol) and, at the highest dose tested (0.56 nmol), they had a greater reduction in food intake than did HWS chicks. HWS chicks responded with a similar magnitude of food intake reduction that was independent of NPS dose. Although water intake was reduced concurrently with food intake after central NPS in both lines, blood glucose concentrations were not affected. Hypothalamic signalling was different between the lines. Although both lines respond to central NPS with decreased c-Fos immunoreactivity in the lateral hypothalamus, the periventricular nucleus had increased c-Fos immunoreactivity in LWS but not HWS chicks. After central NPS treatment, there was increased c-Fos immunoreactivity in the paraventricular nucleus in HWS but not LWS chicks. These data support the notion of differences in the central NPS system between the LWS and HWS lines and infer that central NPS may differentially affect appetite-related processes in other species that contain hypo- and hyperphagic individuals.
M A Cline; B C Prall; M L Smith; W A Calchary; P B Siegel
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Publication Detail:
Type:  Journal Article     Date:  2008-04-28
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  20     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-09-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  904-8     Citation Subset:  IM    
Department of Biology, Radford University, Radford, VA, USA.
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MeSH Terms
Appetite / drug effects*,  physiology
Blood Glucose / analysis,  drug effects
Body Weight* / drug effects,  genetics
Dose-Response Relationship, Drug
Drinking / drug effects
Eating / drug effects
Hypothalamus / drug effects,  metabolism
Injections, Intraventricular
Neuropeptides / administration & dosage,  pharmacology*
Proto-Oncogene Proteins c-fos / metabolism
Selection, Genetic
Reg. No./Substance:
0/Blood Glucose; 0/Neuropeptides; 0/Proto-Oncogene Proteins c-fos; 0/neuropeptide S, human

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