Document Detail

Differential alterations of common carotid and femoral artery distensibility in 12-week-old spontaneously hypertensive rats.
MedLine Citation:
PMID:  9488220     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In essential hypertension, the mechanical properties of the radial artery have been shown to be largely unaltered, whereas more controversial and less reliable data have been obtained for the common carotid artery. We therefore examined the distensibility/pressure relationships of the predominantly elastic common carotid artery and of the predominantly muscle-type femoral artery in 12-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). METHODS: Eleven 12-week-old SHR and 10 age-matched WKY rats were anesthetized with sodium pentobarbitone. Blood pressure and pulse rate were measured by catheters inserted in the common carotid and in the femoral arteries, while contralateral arterial diameter was continuously recorded via an echo-tracking device. Arterial compliance was derived according to the Langewouters formula, and its values were normalized for the diameter, to obtain distensibility/pressure curves and to calculate the distensibility index. The Peterson elastic modulus was also calculated in order to obtain a pressure-independent estimate of arterial mechanical properties. RESULTS: Femoral artery distensibility/pressure curves and distensibility index were similar in the two groups of rats, the latter being 1.13+/-0.13 mm/mmHg10(-3) in SHR and 1.28+/-0.15 mm/mmHg10(-3) in WKY rats (means+/-SEM; NS). In contrast, in SHR, common carotid artery mechanical properties were clearly impaired, as shown by a marked reduction in distensibility index (2.55+/-0.16 mm/mmHg10(-3) in SHR versus 3.4+/-0.3 mm/mmHg10(-3) in WKY rats; P< 0.05), and by a significant increase in the Peterson elastic modulus. CONCLUSIONS: In the SHR model, high blood pressure alters the mechanics of large arteries even in the relatively early stage of the disease; however, the alterations are not homogeneous inasmuch elastic-type vessels are affected to a much greater extent than muscle-type vessels.
M L Stella; L Mircoli; A A Mangoni; C Giannattasio; A U Ferrari; G Mancia
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  15     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1665-9     Citation Subset:  IM    
CNR and Ospedale Maggiore di Milano, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Carotid Artery, Common / physiopathology*,  ultrasonography
Disease Models, Animal
Femoral Artery / physiopathology*,  ultrasonography
Hypertension / physiopathology*,  ultrasonography
Muscle, Smooth, Vascular / physiopathology
Rats, Inbred SHR
Rats, Inbred WKY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of cigarette smoking on carotid and radial artery distensibility.
Next Document:  The role of platelet-derived growth factor-BB-induced increase in cytosolic free Ca2+ in activation ...