Document Detail

Differential accumulation of radiopaque contrast material in acute myocardial infarction.
MedLine Citation:
PMID:  758769     Owner:  NLM     Status:  MEDLINE    
The differential accumulation of radiographic contrast materials in ischemically damaged and normal myocardium was assessed with direct measurement (fluorescent excitation analysis) of the iodine content of tissue samples from dogs with 48 hour old myocardial infarctions. Tissue samples were obtained 10, 30, 60 and 180 minutes after the intravenous administration of 2 ml/kg body weight of diatrizoate meglumine and sodium (Renografin-76). At all time intervals, the iodine concentration of infarcted tissue was at least threefold greater than that of normal myocardium. At 180 minutes the ratio between iodine concentration in infarcted myocardium and that in normal myocardium was 8.5 and between that in infarcted myocardium and that in blood was 2.6. The iodine concentration in the liver was similar to or greater than that in the infarcted area at time intervals after 10 minutes. These results suggest that the intravenous administration of contrast material may facilitate the identification of acutely infarcted myocardium with computerized X-ray transmission tomography.
C B Higgins; M Sovak; W Schmidt; P T Siemers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  43     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-02-23     Completed Date:  1979-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  AIM; IM    
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MeSH Terms
Contrast Media / metabolism*
Diatrizoate / metabolism
Diatrizoate Meglumine / metabolism
Heart / radiography*
Iodine / blood,  metabolism
Liver / metabolism
Myocardial Infarction / metabolism,  radiography*
Myocardium / metabolism*
Time Factors
Tomography, X-Ray Computed
Reg. No./Substance:
0/Contrast Media; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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