| Differential Vbeta T-cell receptor usage during chronic experimental schistosomiasis corresponds with distinct pathological presentations. | |
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MedLine Citation:
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PMID: 11349096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CBA/J male mice with chronic Schistosoma mansoni infections display either moderate splenomegaly syndrome (MSS) or hypersplenomegaly syndrome (HSS). As MSS and HSS mice differ in several immunologic characteristics, we investigated T-cell receptor Vbeta usage. The groups had significantly different expression of several Vbetas, suggesting a relationship between the T-cell repertoire and schistosomiasis pathology. |
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Authors:
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W E Secor; G L Freeman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Infection and immunity Volume: 69 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-11 Completed Date: 2001-06-28 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 4177-9 Citation Subset: IM |
Affiliation:
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Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia 30341-3724, USA. was4@cdc.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD3 / metabolism Male Mice Mice, Inbred C57BL Mice, Inbred CBA Receptors, Antigen, T-Cell, alpha-beta / genetics, metabolism* Schistosoma mansoni / pathogenicity* Schistosomiasis mansoni / immunology, pathology* Splenomegaly / etiology, immunology, pathology* T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Receptors, Antigen, T-Cell, alpha-beta |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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