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Differential Structural Remodeling of the Left-Atrial Posterior Wall in Patients Affected by Mitral Regurgitation with or Without Persistent Atrial Fibrillation: A Morphological and Molecular Study.
MedLine Citation:
PMID:  21954878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Structural Remodeling in Atrial Fibrillation. Introduction: Atrial fibrillation (AF) in mitral regurgitation (MR) is a complex disease where multiple factors may induce left-atrial structural remodeling (SR). We explored the differential SR of the left-atrial posterior wall (LAPW) of patients affected by MR with or without persistent AF, and the expression of key proteins involved in its pathogenesis. Methods and Results: Light microscopy of LAPW samples from 27 patients with MR and persistent AF (group 1), 33 with MR in sinus rhythm (group 2), and 15 autopsy controls (group 3) was used to measure myocyte diameter, percentage of myocytolytic myocytes, interstitial fibrosis, and capillary density; RT-PCR and Western blotting were used to assess the mRNA and protein levels of SOD-1, SOD-2, HO-1, calpain, MMP-2, MMP-9, TIMP-1, TIMP-2, and VEGF; immunofluorescence was used to locate these proteins. Myocyte diameter was similar in groups 1 and 2, but larger than controls. Compared to group 2, group 1 had more myocytolytic myocytes (20.8 ± 5.6% vs 14.7 ± 4.5%; P < 0.0001), increased interstitial fibrosis (10.4 ± 5.1% vs 7.5 ± 4.2%; P < 0.05), and decreased capillary density (923 ± 107 No/mm(2) vs 1,040 ± 100 No/mm(2) ; P < 0.0001). All of the proteins were more expressed in groups 1 and 2 than in controls. The protein and mRNA levels of SOD-1, SOD-2, MMP-2, and MMP-9 were higher in group 1 than in group 2. Conclusions: The LAPW of MR patients with or without AF shows considerable SR. The former has more severe histopathological changes and higher levels of proteins involved in SR, thereby reaching a threshold beyond which the sinus impulse cannot normally activate atrial myocardium. (J Cardiovasc Electrophysiol, Vol. pp. 1-9).
Authors:
Domenico Corradi; Sergio Callegari; Roberta Maestri; David Ferrara; Domenica Mangieri; Rossella Alinovi; Paola Mozzoni; Silvana Pinelli; Matteo Goldoni; Ylenia Adelaide Privitera; Veronica Bartoli; Ettore Astorri; Emilio Macchi; Augusto Vaglio; Stefano Benussi; Ottavio Alfieri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-28
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  -     ISSN:  1540-8167     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
Department of Pathology and Laboratory Medicine, Section of Pathology Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences Italian Workers' Compensation Authority (INAIL) Research Center Department of Clinical Sciences Department of Clinical Medicine, Nephrology and Health Sciences, University Hospital Department of Evolutionary and Functional Biology, Physiology Section; University of Parma, Parma Division of Cardiology, Vaio Hospital, Fidenza (Parma), Italy Cardiothoracic Surgery Unit, Department of Cardiology, San Raffaele University Hospital, Milan, Italy.
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